Pirates vs. Diamondbacks Prediction: Arizona Predicted to Win Tuesday's MLB Matchup [5/27/2025]

MLB action continues on Tuesday at 9:40PM ET as the Pittsburgh Pirates lock horns with the Arizona Diamondbacks at Chase Field.

Corbin Burnes (3-2, 2.73 ERA) will be on the bump for the Diamondbacks, pitting him against Mike Burrows (0-1, 7.20 ERA) for the Pirates.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Pittsburgh-Arizona game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Diamondbacks with a win probability of 70%, compared to 30% for the Pirates."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Pirates vs. Diamondbacks predictions page.

Diamondbacks vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Pirates and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 70% chance of defeating the Pirates.

According to our model, the Diamondbacks (-1.5) have a 52% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Pirates vs. Diamondbacks Odds [5/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Diamondbacks
Run Line	+1.5 (+110)	-1.5 (-125)
Moneyline	+220	-250
Total	o8.5 (-115)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Pirates vs. Diamondbacks matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Pirates vs. Diamondbacks Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Diamondbacks and Pirates at Chase Field is scheduled to begin at 9:40PM ET.

• Who: Pittsburgh Pirates vs. Arizona Diamondbacks
• Date: Tuesday, May 27, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's full preview of Tuesday's Pirates vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. Arizona picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Diamondbacks, with a 70% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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