Pirates vs. Diamondbacks Prediction: Arizona Predicted to Win Monday's MLB Matchup [5/26/2025]

The Arizona Diamondbacks will face the Pittsburgh Pirates in MLB action at Chase Field on Monday, commencing at 8:10PM ET.

Ryne Nelson (1-1, 4.60 ERA) will be on the bump for the Diamondbacks, up against Andrew Heaney (3-3, 2.91 ERA) for the Pirates.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Pittsburgh-Arizona game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Diamondbacks are likely to win, with a probability of 62%, compared to the Pirates' 38%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Pirates vs. Diamondbacks predictions page.

Diamondbacks vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Monday's MLB game between the Pirates and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 62% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 52% chance of going over.

Pirates vs. Diamondbacks Odds [5/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Diamondbacks
Run Line	+1.5 (-118)	-1.5 (+105)
Moneyline	+164	-190
Total	o9 (-122)	u9 (+105)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Diamondbacks Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Diamondbacks matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Pirates vs. Diamondbacks Game-Day Updates and Essential Details

Monday's MLB matchup between the Diamondbacks and Pirates at Chase Field is scheduled to commence at 8:10PM ET.

• Who: Pittsburgh Pirates vs. Arizona Diamondbacks
• Date: Monday, May 26, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Monday's Pirates vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. Arizona picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Diamondbacks, with a 62% win probability, will likely beat the Pirates on Monday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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