Phillies vs. Dodgers prediction: Dodgers favored to win Wednesday's MLB matchup [9/17/2025]

The Los Angeles Dodgers and Philadelphia Phillies will lock horns in MLB action at Dodger Stadium on Wednesday, starting at 10:10PM ET.

Blake Snell (4-4, 2.79 ERA) will be on the bump for the Dodgers, pitting him against Jesús Luzardo (14-6, 4.03 ERA) for the Phillies.

Based on updated simulation results, Dimers' advanced MLB model predicts the Dodgers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Phillies-Dodgers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Dodgers' chance of winning at 59%, with the Phillies at 41%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Phillies vs. Dodgers predictions page.

Dodgers vs. Phillies prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Phillies and Dodgers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Dodgers a 59% chance of beating the Phillies.

According to our model, the Phillies (+1.5) have a 60% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Phillies vs. Dodgers odds [9/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Dodgers
Run Line	+1.5 (-172)	-1.5 (+150)
Moneyline	+128	-148
Total	o7.5 (-119)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Dodgers picks and best bets

Our model's biggest edge in today's Phillies vs. Dodgers matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Phillies vs. Dodgers game-day updates and essential details

Wednesday's MLB matchup between the Dodgers and Phillies at Dodger Stadium is scheduled to commence at 10:10PM ET.

• Who: Philadelphia Phillies vs. Los Angeles Dodgers
• Date: Wednesday, September 17, 2025
• Time: 10:10PM ET/7:10PM PT
• Venue: Dodger Stadium

Dimers' full preview of Wednesday's Phillies vs. Dodgers matchup includes our prediction, picks and the latest betting odds.

Before making any Phillies vs. Dodgers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Dodgers, with a 59% win probability, will likely beat the Phillies on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Dodgers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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