Phillies vs. Astros Prediction: Philadelphia Predicted to Win Wednesday's MLB Matchup [6/25/2025]

The Houston Astros and Philadelphia Phillies will lock horns in MLB action at Daikin Park on Wednesday, starting at 8:10PM ET.

Colton Gordon (2-1, 4.54 ERA) will start for the Astros, up against Zack Wheeler (7-2, 2.61 ERA) for the Phillies.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Phillies-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 55%, with the Astros at 45%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Phillies vs. Astros predictions page.

Astros vs. Phillies Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Phillies and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 55% chance of beating the Astros.

According to our model, the Astros (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 51% chance of staying under.

Phillies vs. Astros Odds [6/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Astros
Run Line	-1.5 (+114)	+1.5 (-130)
Moneyline	-155	+132
Total	o7.5 (+100)	u7.5 (-122)

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Astros Picks and Best Bets

Our model's strongest edge in today's Phillies vs. Astros matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Phillies vs. Astros Game-Day Updates and Essential Details

Wednesday's MLB game between the Astros and Phillies at Daikin Park is scheduled to start at 8:10PM ET.

• Who: Philadelphia Phillies vs. Houston Astros
• Date: Wednesday, June 25, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's full preview of Wednesday's Phillies vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Phillies vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Phillies, with a 55% win probability, will likely beat the Astros on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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