Phillies vs. Astros Prediction: Houston Predicted to Win Thursday's MLB Matchup [6/26/2025]

The Houston Astros will square off with the Philadelphia Phillies in MLB action at Daikin Park on Thursday, commencing at 2:10PM ET.

Hunter Brown (8-3, 1.88 ERA) will start for the Astros, pitting him against Cristopher Sánchez (6-2, 2.88 ERA) for the Phillies.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Phillies-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Astros with a win probability of 59% and the Phillies with 41%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Phillies vs. Astros predictions page.

Astros vs. Phillies Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's MLB matchup between the Phillies and Astros 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Astros a 59% chance of defeating the Phillies.

According to our model, the Phillies (+1.5) have a 62% chance of covering the run line, while the over/under total of 7 runs has a 54% chance of going over.

Phillies vs. Astros Odds [6/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Astros
Run Line	+1.5 (-178)	-1.5 (+160)
Moneyline	+134	-150
Total	o7 (-115)	u7 (-101)

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Astros Picks and Best Bets

Our model's strongest edge in today's Phillies vs. Astros matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Phillies vs. Astros Game-Day Updates and Essential Details

Thursday's MLB action between the Astros and Phillies at Daikin Park is scheduled to commence at 2:10PM ET.

• Who: Philadelphia Phillies vs. Houston Astros
• Date: Thursday, June 26, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Thursday's Phillies vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Phillies vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 59% win probability, will likely beat the Phillies on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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