Phillies vs. Rockies Prediction: Philadelphia Predicted to Win Wednesday's MLB Matchup [5/21/2025]

MLB action continues on Wednesday at 8:40PM ET as the Philadelphia Phillies lock horns with the Colorado Rockies at Coors Field.

Carson Palmquist (0-1, 11.25 ERA) will be the starting pitcher for the Rockies, while the Phillies have opted for Taijuan Walker (1-3, 2.62 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Philadelphia-Colorado game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 59%, with the Rockies at 41%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Phillies vs. Rockies predictions page.

Rockies vs. Phillies Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Phillies and Rockies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Phillies a 59% chance of defeating the Rockies.

According to our model, the Rockies (+1.5) have a 51% chance of covering the run line, while the 11-run over/under has a 54% chance of staying under.

Phillies vs. Rockies Odds [5/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Rockies
Run Line	-1.5 (-142)	+1.5 (+120)
Moneyline	-200	+170
Total	o11 (-118)	u11 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Phillies vs. Rockies Picks and Best Bets

Our model's strongest edge in today's Phillies vs. Rockies matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Phillies vs. Rockies Game-Day Updates and Essential Details

Wednesday's MLB action between the Rockies and Phillies at Coors Field is scheduled to commence at 8:40PM ET.

• Who: Philadelphia Phillies vs. Colorado Rockies
• Date: Wednesday, May 21, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: Coors Field

Dimers.com's full preview of Wednesday's Phillies vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Philadelphia vs. Colorado picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Phillies, with a 59% win probability, will likely beat the Rockies on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most accurate probabilities for the World Series, American League, National League and each division.