Phillies vs. Diamondbacks prediction: Why Philadelphia is favored to win Sunday's MLB matchup [9/21/2025]

The Arizona Diamondbacks will take on the Philadelphia Phillies, in what is expected to be a close MLB game, at Chase Field on Sunday, beginning at 4:10PM ET.

Eduardo Rodriguez (8-8, 5.12 ERA) will get the ball for the Diamondbacks, while the Phillies will counter with Ranger Suárez (12-6, 2.84 ERA).

Based on the latest simulations, Dimers' proven MLB model predicts the Phillies as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Phillies-Diamondbacks game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Phillies with a win probability of 54%, while the Diamondbacks have 46%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Phillies vs. Diamondbacks predictions page.

Diamondbacks vs. Phillies prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Sunday's MLB game between the Phillies and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Phillies a 54% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 59% chance of covering the run line, while the 8.5-run over/under has a 56% chance of going over.

Phillies vs. Diamondbacks odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Diamondbacks
Run Line	-1.5 (+135)	+1.5 (-144)
Moneyline	-130	+110
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Phillies vs. Diamondbacks matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Phillies vs. Diamondbacks game-day updates and essential details

Sunday's MLB game between the Diamondbacks and Phillies at Chase Field is scheduled to begin at 4:10PM ET.

• Who: Philadelphia Phillies vs. Arizona Diamondbacks
• Date: Sunday, September 21, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Chase Field

Dimers' in-depth preview of Sunday's Phillies vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Phillies vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Phillies, with a 54% win probability, will likely beat the Diamondbacks on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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