Phillies vs. Diamondbacks prediction: Why Arizona is favored to win Friday's MLB matchup [9/19/2025]

The Arizona Diamondbacks and Philadelphia Phillies will lock horns in MLB action at Chase Field on Friday, starting at 9:40PM ET.

Ryne Nelson (7-3, 3.34 ERA) will start for the Diamondbacks, up against Taijuan Walker (5-8, 4.17 ERA) for the Phillies.

Based on the latest simulation results, Dimers' proven MLB model projects the Diamondbacks as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Phillies vs. Diamondbacks predictions page.

Diamondbacks vs. Phillies prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Phillies and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Diamondbacks a 51% chance of defeating the Phillies.

According to our model, the Phillies (+1.5) have a 65% chance of covering the run line, while the 9-run over/under has a 58% chance of going over.

Phillies vs. Diamondbacks odds [9/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Diamondbacks
Run Line	+1.5 (-190)	-1.5 (+158)
Moneyline	+108	-124
Total	o9 (-120)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Phillies vs. Diamondbacks matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Phillies vs. Diamondbacks game-day updates and essential details

Friday's MLB matchup between the Diamondbacks and Phillies at Chase Field is scheduled to start at 9:40PM ET.

• Who: Philadelphia Phillies vs. Arizona Diamondbacks
• Date: Friday, September 19, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers' comprehensive preview of Friday's Phillies vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Phillies vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 51% win probability, will likely beat the Phillies on Friday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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