Philadelphia Eagles vs. Tampa Bay Buccaneers early prediction: Expert picks for NFL Week 4, 2025

The Philadelphia Eagles and Tampa Bay Buccaneers will meet in Week 4 of the NFL season at Raymond James Stadium on Sunday, September 28, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Eagles as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Eagles vs. Buccaneers predictions page.

Philadelphia vs. Tampa Bay early predictions

Leveraging trusted machine learning and analysis, we have simulated the Eagles vs. Bucs game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Eagles 54%, Buccaneers 46%
• Predicted final score: Eagles 24-23 Buccaneers
• Spread: Eagles (-2.5) 40%, Buccaneers (+2.5) 60%
• Total points (48.5): Over 50%, Under 50%

As of September 21, 2025, these Eagles-Buccaneers numbers and predictions reflect the latest data and insights available.

Eagles vs. Bucs Week 4 details

The NFL Week 4 game between the Buccaneers and Eagles at Raymond James Stadium is scheduled for September 28, 2025.

• Who: Philadelphia Eagles vs. Tampa Bay Buccaneers
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Raymond James Stadium

Eagles vs. Bucs opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Eagles -2.5 (-115), Buccaneers +2.5 (-105)
• Moneyline: Eagles -148, Buccaneers +124
• Total: Over/Under 48.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Eagles, with a 54% win probability, will likely beat the Buccaneers in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Eagles vs. Buccaneers matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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