Eagles vs. Chiefs prediction: Philadelphia favored to win in NFL Week 2, 2025

The Kansas City Chiefs will face the Philadelphia Eagles in NFL Week 2 action at GEHA Field at Arrowhead Stadium on Sunday, starting at 4:25PM ET.

Based on the latest simulation results, Dimers' proven NFL model projects the Eagles as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Eagles-Chiefs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Eagles with a win probability of 60%, while the Chiefs have 40%."

This gameday Eagles vs. Chiefs betting preview builds on my Eagles vs. Chiefs prediction that was released earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Eagles vs. Chiefs predictions page.

Eagles vs. Chiefs Predictions

Since our Eagles-Chiefs predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Eagles and Chiefs 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Eagles a 60% chance of defeating the Chiefs in Week 2 of the NFL season. Our predicted final score has the Eagles winning 23-21.

According to our model, the Eagles (-1.5) have a 53% chance of covering the spread, while the over/under total of 46.5 points has a 56% chance of staying under.

Eagles vs. Chiefs odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Eagles	Chiefs
Spread	-1.5 (-110)	+1.5 (-105)
Moneyline	-124	+110
Total	o46.5 (-115)	u46.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Eagles vs. Chiefs picks and best bets

Our model's strongest edge in today's Eagles vs. Chiefs matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Eagles vs. Chiefs TD scorers

Who will score the first touchdown in Eagles vs. Chiefs?

According to our model, Philadelphia's Saquon Barkley is most likely to score the first touchdown in Eagles vs. Chiefs.

Our projections give Barkley a 13.2% chance of getting in for six first at GEHA Field at Arrowhead Stadium, while the Eagles running back is a 55.2% chance of reaching the end zone at any point during the game.

First touchdown scorer predictions

Philadelphia Eagles

Player	First TD Probability
Saquon Barkley (RB)	13.2%
Jalen Hurts (QB)	12.8%
A.J. Brown (WR)	7.0%

Kansas City Chiefs

Player	First TD Probability
Kareem Hunt (RB)	7.3%
Hollywood Brown (WR)	7.2%
Travis Kelce (TE)	7.2%

Anytime touchdown scorer predictions

Philadelphia Eagles

Player	Anytime TD Probability
Saquon Barkley (RB)	55.2%
Jalen Hurts (QB)	54.0%
A.J. Brown (WR)	34.7%

Kansas City Chiefs

Player	Anytime TD Probability
Kareem Hunt (RB)	32.4%
Hollywood Brown (WR)	31.9%
Travis Kelce (TE)	31.9%

Eagles vs Chiefs player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Eagles and Chiefs. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Eagles-Chiefs page now to access every player prop projection.

Eagles vs. Chiefs quarterbacks

Of the starting quarterbacks, the Eagles' Jalen Hurts is projected to throw for fewer yards than the Chiefs' Patrick Mahomes.

Eagles rushing

Saquon Barkley, Jalen Hurts and AJ Dillon are projected to be the leading rushers for the Eagles.

Player	Position
Saquon Barkley	RB
Jalen Hurts	QB
AJ Dillon	RB

Chiefs rushing

Isiah Pacheco, Kareem Hunt and Patrick Mahomes are expected to lead the Chiefs in rushing yards.

Player	Position
Isiah Pacheco	RB
Kareem Hunt	RB
Patrick Mahomes	QB

Eagles receiving

A.J. Brown, DeVonta Smith, Grant Calcaterra, Saquon Barkley and Jahan Dotson are projected to top the receiving yards for the Eagles.

Player	Position
A.J. Brown	WR
DeVonta Smith	WR
Grant Calcaterra	TE
Saquon Barkley	RB
Jahan Dotson	WR

Chiefs receiving

Hollywood Brown, Travis Kelce, JuJu Smith-Schuster, Tyquan Thornton and Noah Gray are projected to lead the Chiefs in receiving yards.

Player	Position
Hollywood Brown	WR
Travis Kelce	TE
JuJu Smith-Schuster	WR
Tyquan Thornton	WR
Noah Gray	TE

Eagles vs. Chiefs game-day updates and essential details

The NFL Week 2 game between the Chiefs and Eagles at GEHA Field at Arrowhead Stadium is scheduled to start at 4:25PM ET.

• Who: Philadelphia Eagles vs. Kansas City Chiefs
• Date: Sunday, September 14, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: GEHA Field at Arrowhead Stadium

Dimers' in-depth preview of this week's Eagles vs. Chiefs matchup includes our prediction, picks and the latest betting odds.

Before making any Eagles vs. Chiefs picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Eagles, with a 60% win probability, will likely beat the Chiefs in Week 2 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Eagles vs. Chiefs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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