Philadelphia Eagles vs. Kansas City Chiefs early prediction: Expert picks for NFL Week 2, 2025

The Philadelphia Eagles and Kansas City Chiefs will meet in Week 2 of the NFL season at GEHA Field at Arrowhead Stadium on Sunday, September 14, 2025, starting at 4:25PM ET.

Initial simulations from Dimers' trusted NFL model favor the Eagles as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Eagles vs. Chiefs predictions page.

Philadelphia vs. Kansas City early predictions

Leveraging trusted machine learning and analysis, we have simulated the Eagles vs. Chiefs game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Eagles 46%, Chiefs 54%
• Predicted final score: Eagles 22-22 Chiefs
• Spread: Eagles (+1.5) 53%, Chiefs (-1.5) 47%
• Total points (47.5): Over 46%, Under 54%

As of September 7, 2025, these Eagles-Chiefs figures and predictions reflect the latest data and insights available.

Eagles vs. Chiefs Week 2 details

The NFL Week 2 game between the Chiefs and Eagles at GEHA Field at Arrowhead Stadium is scheduled for September 14, 2025.

• Who: Philadelphia Eagles vs. Kansas City Chiefs
• Date: Sunday, September 14, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: GEHA Field at Arrowhead Stadium

Eagles vs. Chiefs opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Eagles +1.5 (-110), Chiefs -1.5 (+100)
• Moneyline: Eagles +105, Chiefs -108
• Total: Over/Under 47.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 2 betting promos and codes

Make the most of Dimers' Eagles vs. Chiefs predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $300 in Bonus Bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in Bonus Bets win or lose.

Conclusion

We predict the Chiefs, with a 54% win probability, will likely beat the Eagles in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Eagles vs. Chiefs matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.