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76ers vs. Knicks Prediction: New York to Win, Jalen Brunson Projected for Big Game in Wednesday's NBA Matchup [2/26/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Our expert prediction for Wednesday's Philadelphia 76ers vs New York Knicks matchup.
The New York Knicks and Philadelphia sixers will meet in NBA action at Madison Square Garden on Wednesday, starting at 7:00PM ET.
Based on the latest simulations and today’s injury reports, Dimers' proven NBA model (see Dimers Pro for full access) projects the Knicks as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Philadelphia-New York game 10,000 times," said Damien Souness from Dimers.
"With the latest updates and numerous other variables, we estimate the Knicks' chance of winning at 75%, with the 76ers at 25%."
This prediction follows the latest NBA Injury Report, which suggests the Knicks lineup will feature stars like Jalen Brunson, Mikal Bridges and OG Anunoby, while the 76ers will be led by Tyrese Maxey, Paul George and Quentin Grimes.
For a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive 76ers vs. Knicks predictions page.
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Knicks vs. Sixers Prediction: Who Will Win, Cover the Spread?
Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's NBA matchup between the 76ers and Knicks 10,000 times as part of our NBA predictions coverage.
Our independent predictive model currently gives the Knicks a 75% chance of beating the 76ers. Our predicted final score has the Knicks winning 117-110.
According to our model, the 76ers (+8) have a 53% chance of covering the spread, while the over/under total of 227.5 points has a 51% chance of staying under.
76ers vs. Knicks Odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | 76ers | Knicks |
|---|---|---|
| Spread | +8 (-110) | -8 (-110) |
| Moneyline | +260 | -320 |
| Total | o227.5 (-110) | u227.5 (-110) |
All odds are correct at the time of publication and are subject to change.
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76ers vs. Knicks Picks and Best Bets
Our model's biggest edge in today's 76ers vs. Knicks matchup is on the over/under.
Our expert predictions, matched against the latest odds, reveal the best NBA picks for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
76ers vs. Knicks Player Props
NBA prop bets are an enjoyable way to wager on the 76ers vs. Knicks game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Madison Square Garden.
Tyrese Maxey is expected to lead the 76ers in scoring, while Jalen Brunson is projected to be the top scorer for the Knicks.
Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.
Calling Our Shot's Best Bets Video
Calling Our Shot produces daily NBA betting content, including the latest predictions featured below.
Sixers vs. Knicks Game-Day Updates and Essential Details
Wednesday's action between the Knicks and 76ers at Madison Square Garden is scheduled to begin at 7:00PM ET.
- Who: Philadelphia 76ers vs. New York Knicks
- Date: Wednesday, February 26, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Madison Square Garden
Dimers.com's full preview of Wednesday's 76ers vs. Knicks matchup includes our prediction, picks and the latest betting odds.
Before making any Philadelphia vs. New York picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Knicks, with a 75% win probability, will likely beat the 76ers on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Knicks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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