St George Illawarra Dragons vs. Penrith Panthers prediction: Panthers favored to win Saturday's NRL Round 27 matchup [9/6/2025]

The St George Illawarra Dragons will square off with the favored Penrith Panthers in National Rugby League (NRL) action at WIN Stadium on Saturday, commencing at 1:00AM ET.

Based on updated simulations, Dimers' proven NRL model predicts the Panthers as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Panthers vs. Dragons predictions page.

Dragons vs. Panthers prediction: Who will win Round 27 game?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's NRL matchup between the Panthers and Dragons 10,000 times as part of our NRL predictions coverage.

Our independent predictive model gives the Panthers an 81% chance of beating the Dragons.

According to our model, the Dragons (+15.5) have a 56% chance of covering the spread, while the over/under total of 49.5 has a 52% chance of staying under.

Panthers vs. St George odds

We have sourced the best NRL odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Dragons vs. Panthers game-day updates and essential details

Saturday's Australian rugby league game between the Dragons and Panthers at WIN Stadium is scheduled to begin at 1:00AM ET.

• Who: Penrith Panthers vs. St George Illawarra Dragons
• Date: Saturday, September 6, 2025
• Time: 1:00AM ET/10:00PM PT
• Venue: WIN Stadium

The NRL is available to bet on in the US through all major sportsbooks, with there even being games played in Vegas each season as of 2024.

Dimers.com's in-depth preview of Saturday's Panthers vs. Dragons matchup includes our prediction, picks and the latest betting odds.

Before making any Panthers vs. St George picks, be sure to check out the latest NRL predictions and betting advice from Dimers Pro.

Conclusion

We predict the Panthers, with an 81% win probability, will likely beat the Dragons on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Dragons insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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