Canterbury Bulldogs vs. Penrith Panthers prediction: Panthers favored to win Sunday's NRL Round 29 matchup [9/21/2025]

The Canterbury Bulldogs will square off with the favored Penrith Panthers in National Rugby League (NRL) action at Stadium Australia on Sunday, beginning at 2:05AM ET.

Based on updated simulation results, Dimers' advanced NRL model predicts the Panthers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Panthers-Bulldogs game," said Pat Sharyon from Dimers.

"After accounting for recent updates and other variables, our prediction shows the Panthers with a win probability of 74%, while the Bulldogs have 26%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Panthers vs. Bulldogs predictions page.

Bulldogs vs. Panthers prediction: Who will win Round 29 game?

Using trusted machine learning and data, we have simulated the outcome of Sunday's NRL game between the Panthers and Bulldogs 10,000 times as part of our NRL predictions coverage.

Our independent predictive model currently gives the Panthers a 74% chance of beating the Bulldogs.

According to our model, the Panthers (-8.5) have a 54% chance of covering the spread, while the 39.5- over/under has a 56% chance of going over.

Panthers vs. Bulldogs odds

We have sourced the best NRL odds in America for this game, which are listed here:

Bet Type	Panthers	Bulldogs
H2H (Moneyline)	-278	+205
Line (Spread)	-8.5 (-115)	+8.5 (-110)
Total	o39.5 (-120)	u39.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Bulldogs vs. Panthers game-day updates and essential details

Sunday's Australian rugby league matchup between the Bulldogs and Panthers at Stadium Australia is scheduled to begin at 2:05AM ET.

• Who: Penrith Panthers vs. Canterbury Bulldogs
• Date: Sunday, September 21, 2025
• Time: 2:05AM ET/11:05PM PT
• Venue: Stadium Australia

The NRL is available to bet on in the US through all major sportsbooks, with there even being games played in Vegas each season as of 2024.

Dimers' in-depth preview of Sunday's Panthers vs. Bulldogs matchup includes our prediction, picks and the latest betting odds.

Before making any Panthers vs. Bulldogs picks, be sure to check out the latest NRL predictions and betting advice from Dimers Pro.

Conclusion

We predict the Panthers, with a 74% win probability, will likely beat the Bulldogs on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Bulldogs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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