Patriots vs. Bills Predictions and Odds - Jan 15, 2022

NFL action continues on Saturday at 8:15PM EST as the New England Patriots take on the favored Buffalo Bills in the Wild Card round of the 2021 NFL Playoffs at Highmark Stadium.

Dimers' free betting picks for Patriots vs. Bills, plus game predictions and best odds, are featured in this article.

Today's New England vs. Buffalo betting analysis is sponsored by FanDuel Sportsbook, which has an awesome Bet $5, Win $150 promo for new customers during this year's NFL Playoffs.

Who will win Patriots vs. Bills?

Based on state-of-the-art computer power and data, Dimers.com has simulated Saturday's Patriots-Bills NFL matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Bills a 67% chance of winning against the Patriots.

MORE: Patriots vs. Bills Simulated 10K Times

Point Spread, Moneyline and Over/Under

The Bills are -4 favorites versus the Patriots, with -110 at DraftKings Sportsbook currently the best odds available.

For the underdog Patriots (+4) to cover the spread, DraftKings Sportsbook also currently has the best odds on offer at -110.

bet365 currently has the best moneyline odds for the Bills at -222, which means you can risk $222 to win $100, for a total payout of $322, if they get the W.

Meanwhile, bet365 also has the best moneyline odds for the Patriots at +180, where you can put down $100 to profit $180, earning a total payout of $280, if they win.

The Over/Under for total points scored is set at 43.5 with BetMGM, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the online sportsbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the Bills (-4) are a 51% chance of covering the spread, while the 43.5-point Over/Under is a 52% chance of going Under.

MORE: Super Bowl 56 Probabilities and Odds

Best Bets for Patriots vs. Bills

• Spread: Bills -4 at -110 with DraftKings Sportsbook (51% probability)
• Moneyline: Bills Win at -222 with bet365 (67% probability)
• Over/Under: Under 43.5 at -110 with BetMGM (52% probability)

Patriots vs. Bills Score Prediction

Dimers.com's predicted final score for New England vs. Buffalo at Highmark Stadium this Saturday has the Bills prevailing 23-19.

Use our dynamic widget below to explore the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Patriots-Bills matchup, including pre-game predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so check this page for the latest betting analysis before Patriots vs. Bills on Saturday January 15, 2022.

Bet $5, Win $150 on Patriots or Bills to Win

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Patriots vs. Bills 2022 Game Info

When do the Bills play the Patriots?

• Date: Saturday January 15, 2022
• Time: 8:15PM EST / 5:15PM PST
• Venue: Highmark Stadium

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What other NFL games are on today?

Now you've got the 411 on Patriots vs. Bills, check out the latest betting predictions for all upcoming NFL games in Dimers' NFL Bet Hub. There you can find probabilities and odds, as well as our best bets for every single NFL matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!