Patriots vs. Bills Predictions and Odds - Dec 6, 2021

The Buffalo Bills square off with the New England Patriots in NFL Week 13 action at Highmark Stadium on Monday, commencing at 8:15 PM EST.

Dimers' best betting picks for Patriots vs. Bills, plus game predictions, best odds and player props, are featured in this article.

Who will win Patriots vs. Bills?

Using cutting-edge machine learning and data, Dimers.com has simulated Monday's Patriots-Bills NFL game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Bills a 63% chance of getting the W against the Patriots.

MORE: Free Betting Guide for Patriots vs. Bills

Point Spread, Moneyline and Over/Under

The Bills are -3 favorites versus the Patriots, with -102 at FanDuel Sportsbook the best odds available.

For the underdog Patriots (+3) to cover the spread, PointsBet has the best odds on offer at -110.

PointsBet has the best moneyline odds for the Bills at -140, which means you can risk $140 to win $100, for a total payout of $240, if they get the W.

Elsewhere, FanDuel Sportsbook has the best moneyline odds for the Patriots at +128, where you can bet $100 to profit $128, earning a total payout of $228, if they win.

The Over/Under for total points scored is set at 39.5 with PointsBet, which has the best odds for the Over at -110, while FanDuel Sportsbook has the best odds for the Under at -105.

As always, make sure you check all the legal sportbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the bookmakers have got it right and both the Patriots and Bills are a 50% chance of covering the spread, while the Over/Under total of 39.5 points is a 54% chance of going Over.

MORE: Predictions for Every NFL Matchup

Best Bets for Patriots vs. Bills

• Spread: Bills -3 at -102 with FanDuel Sportsbook (50% probability)
• Moneyline: Bills Win at -140 with PointsBet (63% probability) 🔥
• Over/Under: Over 39.5 at -110 with PointsBet (54% probability)

If you see a 🔥, you know it's one of Dimers' best free picks of the day across all major pro and college sports.

Patriots vs. Bills Score Prediction

Dimers.com's predicted final score for New England vs. Buffalo at Highmark Stadium this Monday has the Bills prevailing 21-18.

Use our dynamic widget below to see the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Patriots-Bills matchup, including pre-game predictions, free picks, and live win probabilities.

Patriots vs. Bills Player Props

Who will score an anytime touchdown in Patriots vs. Bills? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Patriots and Bills, as well as projected player stats.

And you know what, we provide this information to you for FREE to help you discover the best prop picks for Monday's game.

According to DimersBOT, Buffalo's Josh Allen is most likely to score the first TD in Patriots vs. Bills.

DimersBOT gives Allen a 10.5% chance of scoring the first TD at Highmark Stadium, while the Bills QB is a 39.4% chance of reaching the end zone at any point in the game.

First Touchdown Scorer Probabilities

New England Patriots

• Damien Harris: 9.8% probability
• Rhamondre Stevenson: 8.1% probability
• Jakobi Meyers: 4.6% probability
• Jonnu Smith: 4.6% probability
• Hunter Henry: 4.4% probability

Buffalo Bills

• Josh Allen: 10.5% probability
• Stefon Diggs: 9.4% probability
• Devin Singletary: 7.2% probability
• Matt Breida: 6.1% probability
• Emmanuel Sanders: 5.8% probability

Anytime Touchdown Scorer Probabilities

New England Patriots

• Damien Harris: 37.0% probability
• Rhamondre Stevenson: 32.4% probability
• Jakobi Meyers: 21.5% probability
• Hunter Henry: 18.9% probability
• Kendrick Bourne: 18.6% probability

Buffalo Bills

• Josh Allen: 39.4% probability
• Stefon Diggs: 37.1% probability
• Devin Singletary: 27.2% probability
• Cole Beasley: 25.0% probability
• Emmanuel Sanders: 23.4% probability

Projected Box Score

Of the starting quarterbacks, the Patriots' Mac Jones is projected for 193 passing yards and 1.0 passing touchdowns. The Bills' Josh Allen is expected to throw for 240 yards and 1.5 TDs.

Patriots Starting QB

• Mac Jones: 193 Passing Yards, 1.0 Passing TDs

Bills Starting QB

• Josh Allen: 240 Passing Yards, 1.5 Passing TDs

Patriots Rushing

• Damien Harris: 55 Rushing Yards, 0.4 TDs
• Rhamondre Stevenson: 45 Rushing Yards, 0.3 TDs
• Mac Jones: 13 Rushing Yards, 0.1 TDs

Bills Rushing

• Devin Singletary: 46 Rushing Yards, 0.2 TDs
• Matt Breida: 40 Rushing Yards, 0.2 TDs
• Josh Allen: 40 Rushing Yards, 0.4 TDs

Patriots Receiving

• Jakobi Meyers: 42 Receiving Yards, 0.2 TDs
• Kendrick Bourne: 39 Receiving Yards, 0.1 TDs
• Nelson Agholor: 34 Receiving Yards, 0.2 TDs
• Hunter Henry: 29 Receiving Yards, 0.2 TDs
• Jonnu Smith: 19 Receiving Yards, 0.1 TDs

Bills Receiving

• Stefon Diggs: 74 Receiving Yards, 0.4 TDs
• Cole Beasley: 40 Receiving Yards, 0.2 TDs
• Emmanuel Sanders: 35 Receiving Yards, 0.2 TDs
• Dawson Knox: 31 Receiving Yards, 0.2 TDs
• Gabriel Davis: 21 Receiving Yards, 0.1 TDs

Remember, DimersBOT updates regularly, so keep checking this page for the latest betting insights ahead of Patriots vs. Bills on Monday December 6, 2021.

Patriots vs. Bills 2021 Game Info

When do the Bills play the Patriots?

• Date: Monday December 6, 2021
• Time: 8:15 PM EST / 5:15 PM PST
• Venue: Highmark Stadium

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What other NFL games are on today?

The Patriots and Bills aren't the only two NFL teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single NFL game in our NFL Bet Hub page.

Not only do we provide with you great predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!