Panthers vs. Bills Predictions and Odds - Dec 19, 2021

The Buffalo Bills take on the Carolina Panthers in NFL Week 15 action at Highmark Stadium on Sunday, starting at 1:00 PM EST.

Dimers' top betting picks for Panthers vs. Bills, plus our score prediction, best odds and player props, are featured below.

Who will win Panthers vs. Bills?

Based on state-of-the-art computer power and data, Dimers.com has simulated Sunday's Panthers-Bills NFL matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Bills a 90% chance of defeating the Panthers.

MORE: Panthers vs. Bills Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

The Bills are -14 favorites versus the Panthers, with -115 at DraftKings Sportsbook the best odds available.

For the underdog Panthers (+14) to cover the spread, DraftKings Sportsbook also has the best odds on the market at -105.

BetMGM has the best moneyline odds for the Bills at -714. That means you can risk $714 to win $100, for a total payout of $814, if they get the W.

Elsewhere, PointsBet has the best moneyline odds for the Panthers at +600, where you can bet $100 to profit $600, earning a total payout of $700, if they win.

The Over/Under for total points scored is set at 43.5 with BetMGM, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the sportsbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the Panthers (+14) are a 53% chance of covering the spread, while the 43.5-point Over/Under is a 53% chance of going Under.

MORE: Best Bets for Every NFL Game

Best Bets for Panthers vs. Bills

• Spread: Panthers +14 at -105 with DraftKings Sportsbook (53% probability)
• Moneyline: Bills Win at -714 with BetMGM (90% probability)
• Over/Under: Under 43.5 at -110 with BetMGM (53% probability)

Panthers vs. Bills Score Prediction

Dimers.com's predicted final score for Carolina vs. Buffalo at Highmark Stadium on Sunday has the Bills winning 27-14.

Use our widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of this week's Panthers-Bills matchup, including pre-game predictions, top betting picks, and live updates.

Panthers vs. Bills Player Props

Who will score an anytime touchdown in Panthers vs. Bills? The data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Panthers and Bills, as well as projected player stats.

And you know what, we provide this information to you for FREE to help you choose the best prop bets for Sunday's game.

According to DimersBOT, Buffalo's Josh Allen is most likely to score the first TD in Panthers vs. Bills.

DimersBOT gives Allen a 12.7% chance of scoring the first TD at Highmark Stadium, while the Bills QB is a 49.1% chance of scoring an anytime touchdown.

First Touchdown Scorer Probabilities

Carolina Panthers

• Cam Newton: 9.7% probability
• Chuba Hubbard: 6.7% probability
• D.J. Moore: 5.3% probability
• Robby Anderson: 3.7% probability
• Ameer Abdullah: 3.0% probability

Buffalo Bills

• Josh Allen: 12.7% probability
• Stefon Diggs: 12.5% probability
• Devin Singletary: 8.5% probability
• Dawson Knox: 8.0% probability
• Gabriel Davis: 7.2% probability

Anytime Touchdown Scorer Probabilities

Carolina Panthers

• Cam Newton: 42.0% probability
• Chuba Hubbard: 29.9% probability
• D.J. Moore: 24.0% probability
• Robby Anderson: 17.9% probability
• Ameer Abdullah: 15.6% probability

Buffalo Bills

• Josh Allen: 49.1% probability
• Stefon Diggs: 47.8% probability
• Devin Singletary: 36.1% probability
• Dawson Knox: 34.0% probability
• Gabriel Davis: 31.0% probability

Projected Box Score

Of the starting quarterbacks, the Panthers' Cam Newton is projected for 237 passing yards and 0.8 passing touchdowns. The Bills' Josh Allen is expected to throw for 240 yards and 1.8 TDs.

Panthers Starting QB

• Cam Newton: 237 Passing Yards, 0.8 Passing TDs

Bills Starting QB

• Josh Allen: 240 Passing Yards, 1.8 Passing TDs

Panthers Rushing

• Chuba Hubbard: 50 Rushing Yards, 0.3 TDs
• Cam Newton: 38 Rushing Yards, 0.5 TDs
• Ameer Abdullah: 16 Rushing Yards, 0.1 TDs

Bills Rushing

• Josh Allen: 45 Rushing Yards, 0.6 TDs
• Devin Singletary: 43 Rushing Yards, 0.3 TDs
• Matt Breida: 22 Rushing Yards, 0.1 TDs

Panthers Receiving

• D.J. Moore: 70 Receiving Yards, 0.2 TDs
• Robby Anderson: 44 Receiving Yards, 0.2 TDs
• Brandon Zylstra: 29 Receiving Yards, 0.1 TDs
• Tommy Tremble: 19 Receiving Yards, 0.1 TDs
• Ameer Abdullah: 18 Receiving Yards, 0.1 TDs

Bills Receiving

• Stefon Diggs: 79 Receiving Yards, 0.6 TDs
• Gabriel Davis: 44 Receiving Yards, 0.3 TDs
• Dawson Knox: 42 Receiving Yards, 0.4 TDs
• Cole Beasley: 40 Receiving Yards, 0.3 TDs
• Isaiah McKenzie: 15 Receiving Yards, 0.2 TDs

Remember, DimersBOT updates regularly, so check this article for the latest betting insights ahead of Panthers vs. Bills on Sunday December 19, 2021.

Bet $10, Win $200 if Panthers or Bills Score a TD

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a partnership with (such as an online sportsbook), we may earn a referral fee.

Panthers vs. Bills 2021 Game Info

When do the Bills play the Panthers?

• Date: Sunday December 19, 2021
• Time: 1:00 PM EST / 10:00 AM PST
• Venue: Highmark Stadium

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What other NFL games are on today?

The Panthers and Bills aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and top bets for every single NFL matchup in our NFL Bet Hub page.

Not only do we provide with you quality predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!