Oregon vs. Penn State prediction: Why Penn State is favored to win in college football Week 5, 2025

Penn State and Oregon will meet in Week 5 college football action at West Shore Home Field at Beaver Stadium on Saturday, with kickoff at 7:30PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Penn State as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Oregon vs. Penn State predictions page.

Oregon vs. Penn State prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Oregon vs. Penn State 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Penn State a 58% chance of defeating Oregon. Our predicted final score has Penn State winning 27-24.

According to our model, Oregon (+4.5) has a 59% chance of covering the spread, while the 52.5-point over/under has a 53% chance of going over.

Oregon vs. Penn State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Oregon	Penn State
Spread	+4.5 (-112)	-4.5 (-108)
Moneyline	+158	-185
Total	o52.5 (-105)	u52.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Oregon vs. Penn State picks and best bets

Our model's strongest edge in today's Oregon vs. Penn State matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Oregon vs. Penn State game-day updates and essential details

Saturday's college football game between Penn State and Oregon at West Shore Home Field at Beaver Stadium is scheduled to commence at 7:30PM ET.

• Who: Oregon vs. Penn State
• Date: Saturday, September 27, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: West Shore Home Field at Beaver Stadium

Dimers' in-depth preview of Saturday's Oregon vs. Penn State matchup includes our prediction, picks and the latest betting odds.

Before making any Oregon vs. Penn State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Penn State, with a 58% win probability, will likely beat Oregon on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Oregon vs. Penn State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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