Oregon vs. Northwestern prediction: Oregon favored to win in college football Week 3, 2025

Northwestern and Oregon will meet in Week 3 college football action at Northwestern Medicine Field at Martin Stadium on Saturday, beginning at 12:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Oregon as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Oregon vs. Northwestern predictions page.

Oregon vs. Northwestern prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Oregon vs. Northwestern 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Oregon a 95% chance of defeating Northwestern. Our predicted final score has Oregon winning 39-13.

According to our model, Oregon (-24.5) has a 53% chance of covering the spread, while the over/under total of 49.5 points has a 57% chance of staying under.

Oregon vs. Northwestern odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Oregon	Northwestern
Spread	-24.5 (-108)	+24.5 (-122)
Moneyline	-4500	+2000
Total	o49.5 (-122)	u49.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Oregon vs. Northwestern picks and best bets

Our model's biggest edge in today's Oregon vs. Northwestern matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Oregon vs. Northwestern game-day updates and essential details

Saturday's college football matchup between Northwestern and Oregon at Northwestern Medicine Field at Martin Stadium is scheduled to begin at 12:00PM ET.

• Who: Oregon vs. Northwestern
• Date: Saturday, September 13, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Northwestern Medicine Field at Martin Stadium

Dimers' comprehensive preview of Saturday's Oregon vs. Northwestern matchup includes our prediction, picks and the latest betting odds.

Before making any Oregon vs. Northwestern picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Oregon, with a 95% win probability, will likely beat Northwestern on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Oregon vs. Northwestern insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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