Old Dominion vs. Indiana prediction: Why Indiana is favored to win in college football Week 1, 2025

Indiana and Old Dominion will meet in college football action at Memorial Stadium on Saturday, with kickoff at 2:30PM ET.

Based on the latest simulation results, Dimers' proven college football model projects Indiana as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Old Dominion vs. Indiana predictions page.

Old Dominion vs. Indiana prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the outcome of Old Dominion vs. Indiana 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Indiana a 94% chance of beating Old Dominion. Our predicted final score has Indiana winning 38-14.

According to our model, Old Dominion (+24.5) has a 53% chance of covering the spread, while the over/under total of 53.5 points has a 52% chance of staying under.

Old Dominion vs. Indiana odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Old Dominion	Indiana
Spread	+24.5 (-120)	-24.5 (-110)
Moneyline	+1500	-2500
Total	o53.5 (-110)	u53.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Old Dominion vs. Indiana picks and best bets

Our model's biggest edge in today's Old Dominion vs. Indiana matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Old Dominion vs. Indiana game-day updates and essential details

Saturday's college football matchup between Indiana and Old Dominion at Memorial Stadium is scheduled to begin at 2:30PM ET.

• Who: Old Dominion vs. Indiana
• Date: Saturday, August 30, 2025
• Time: 2:30PM ET/11:30AM PT
• Venue: Memorial Stadium

Dimers.com's comprehensive preview of Saturday's Old Dominion vs. Indiana matchup includes our prediction, picks and the latest betting odds.

Before making any Old Dominion vs. Indiana picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Indiana, with a 94% win probability, will likely beat Old Dominion on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Old Dominion vs. Indiana insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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