Oklahoma State vs. Oregon prediction: Oregon favored to win in college football Week 2, 2025

Oregon and Oklahoma State will meet in Week 2 college football action at Autzen Stadium on Saturday, starting at 3:30PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Oregon as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Oklahoma State vs. Oregon predictions page.

Oklahoma State vs. Oregon prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Oklahoma State vs. Oregon 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Oregon a 97% chance of defeating Oklahoma State. Our predicted final score has Oregon winning 45-12.

According to our model, Oregon (-28.5) has a 56% chance of covering the spread, while the over/under total of 55.5 points has a 68% chance of going over.

Oklahoma State vs. Oregon odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Oklahoma State	Oregon
Spread	+28.5 (-110)	-28.5 (-110)
Moneyline	+5500	-10000
Total	o55.5 (-110)	u55.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Oklahoma State vs. Oregon picks and best bets

Our model's strongest edge in today's Oklahoma State vs. Oregon matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Oklahoma State vs. Oregon game-day updates and essential details

Saturday's college football matchup between Oregon and Oklahoma State at Autzen Stadium is scheduled to commence at 3:30PM ET.

• Who: Oklahoma State vs. Oregon
• Date: Saturday, September 6, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Autzen Stadium

Dimers.com's in-depth preview of Saturday's Oklahoma State vs. Oregon matchup includes our prediction, picks and the latest betting odds.

Before making any Oklahoma State vs. Oregon picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Oregon, with a 97% win probability, will likely beat Oklahoma State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Oklahoma State vs. Oregon insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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