Ohio vs. Ohio State prediction: Ohio State favored to win in college football Week 3, 2025

Ohio State and Ohio will meet in Week 3 college football action at Ohio Stadium on Saturday, beginning at 7:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Ohio State as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Ohio vs. Ohio State predictions page.

Ohio vs. Ohio State prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Ohio vs. Ohio State 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Ohio State a 97% chance of defeating Ohio. Our predicted final score has Ohio State winning 38-10.

According to our model, the bookmakers have got it right, and Ohio and Ohio State each have a 50% chance of covering the spread, while the 49.5-point over/under also has an equal 50-50 chance of hitting.

Ohio vs. Ohio State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Ohio	Ohio State
Spread	+28.5 (-110)	-28.5 (-105)
Moneyline	+2200	-4500
Total	o49.5 (-110)	u49.5 (-108)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Ohio vs. Ohio State picks and best bets

Our model's biggest edge in today's Ohio vs. Ohio State matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Ohio vs. Ohio State game-day updates and essential details

Saturday's college football action between Ohio State and Ohio at Ohio Stadium is scheduled to begin at 7:00PM ET.

• Who: Ohio vs. Ohio State
• Date: Saturday, September 13, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Ohio Stadium

Dimers' in-depth preview of Saturday's Ohio vs. Ohio State matchup includes our prediction, picks and the latest betting odds.

Before making any Ohio vs. Ohio State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for Maryland sports fans

To make the most of Saturday's massive day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that secures $300 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Ohio State, with a 97% win probability, will likely beat Ohio on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Ohio vs. Ohio State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay informed with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the most up-to-date probabilities for the national title game and major conferences.