Notre Dame vs. Arkansas prediction: Why Notre Dame is favored to win in college football Week 5, 2025

Arkansas and Notre Dame will meet in Week 5 college football action at Donald W. Reynolds Razorback Stadium on Saturday, beginning at 12:00PM ET.

Based on the latest simulations, Dimers' proven college football model predicts Notre Dame as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Notre Dame vs. Arkansas predictions page.

Notre Dame vs. Arkansas prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Notre Dame vs. Arkansas 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Notre Dame a 53% chance of defeating Arkansas. Our predicted final score has Notre Dame winning 32-30.

According to our model, Arkansas (+5.5) has a 63% chance of covering the spread, while the over/under total of 64.5 points has a 51% chance of going over.

Notre Dame vs. Arkansas odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Notre Dame	Arkansas
Spread	-5.5 (-110)	+5.5 (-110)
Moneyline	-200	+180
Total	o64.5 (-105)	u64.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Notre Dame vs. Arkansas picks and best bets

Our model's biggest edge in today's Notre Dame vs. Arkansas matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Notre Dame vs. Arkansas game-day updates and essential details

Saturday's college football game between Arkansas and Notre Dame at Donald W. Reynolds Razorback Stadium is scheduled to commence at 12:00PM ET.

• Who: Notre Dame vs. Arkansas
• Date: Saturday, September 27, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Donald W. Reynolds Razorback Stadium

Dimers' full preview of Saturday's Notre Dame vs. Arkansas matchup includes our prediction, picks and the latest betting odds.

Before making any Notre Dame vs. Arkansas picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Notre Dame, with a 53% win probability, will likely beat Arkansas on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Notre Dame vs. Arkansas insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay informed with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest predictions for the national title game and major conferences.