Northern Illinois vs. Mississippi State prediction: Why Mississippi State is favored to win in college football Week 4, 2025

Mississippi State and Northern Illinois will lock horns in Week 4 college football action at Davis Wade Stadium at Scott Field on Saturday, beginning at 4:15PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Mississippi State as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Northern Illinois vs. Mississippi State predictions page.

Northern Illinois vs. Mississippi State prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the result of Northern Illinois vs. Mississippi State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Mississippi State a 95% chance of beating Northern Illinois. Our predicted final score has Mississippi State winning 35-12.

According to our model, Northern Illinois (+24.5) has a 54% chance of covering the spread, while the over/under total of 48.5 points has an equal 50-50 chance of hitting.

Northern Illinois vs. Mississippi State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Northern Illinois	Mississippi State
Spread	+24.5 (-110)	-24.5 (-110)
Moneyline	+1400	-2100
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Northern Illinois vs. Mississippi State picks and best bets

Our model's biggest edge in today's Northern Illinois vs. Mississippi State matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Northern Illinois vs. Mississippi State game-day updates and essential details

Saturday's college football matchup between Mississippi State and Northern Illinois at Davis Wade Stadium at Scott Field is scheduled to begin at 4:15PM ET.

• Who: Northern Illinois vs. Mississippi State
• Date: Saturday, September 20, 2025
• Time: 4:15PM ET/1:15PM PT
• Venue: Davis Wade Stadium at Scott Field

Dimers' in-depth preview of Saturday's Northern Illinois vs. Mississippi State matchup includes our prediction, picks and the latest betting odds.

Before making any Northern Illinois vs. Mississippi State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Mississippi State, with a 95% win probability, will likely beat Northern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Northern Illinois vs. Mississippi State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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