Nicholls State vs. Eastern Kentucky prediction: Why Eastern Kentucky is favored to win in college football Week 5, 2025

Eastern Kentucky will face Nicholls State in Week 5 college football action at Roy Kidd Stadium on Saturday, beginning at 6:00PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Eastern Kentucky as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Nicholls State vs. Eastern Kentucky predictions page.

Nicholls State vs. Eastern Kentucky prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the result of Nicholls State vs. Eastern Kentucky 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Eastern Kentucky a 59% chance of beating Nicholls State. Our predicted final score has Eastern Kentucky winning 23-20.

According to our model, the bookmakers have got it right, and Nicholls State and Eastern Kentucky each have a 50% chance of covering the spread, while the 43.5-point over/under has a 54% chance of staying under.

Nicholls State vs. Eastern Kentucky odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Nicholls State	Eastern Kentucky
Spread	+2.5 (+100)	-2.5 (-110)
Moneyline	+116	-135
Total	o43.5 (-110)	u43.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Nicholls State vs. Eastern Kentucky picks and best bets

Our model's biggest edge in today's Nicholls State vs. Eastern Kentucky matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Nicholls State vs. Eastern Kentucky game-day updates and essential details

Saturday's college football matchup between Eastern Kentucky and Nicholls State at Roy Kidd Stadium is scheduled to commence at 6:00PM ET.

• Who: Nicholls State vs. Eastern Kentucky
• Date: Saturday, September 27, 2025
• Time: 6:00PM ET/3:00PM PT
• Venue: Roy Kidd Stadium

Dimers' comprehensive preview of Saturday's Nicholls State vs. Eastern Kentucky matchup includes our prediction, picks and the latest betting odds.

Before making any Nicholls State vs. Eastern Kentucky picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Eastern Kentucky, with a 59% win probability, will likely beat Nicholls State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Nicholls State vs. Eastern Kentucky insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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