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NFL Week 16 2021: Sunday Picks, Predictions and Odds

After an avalanche of football and basketball on Saturday, we go again with a full Sunday slate of picks for the NFL.
As we always do, Dimers.com has simulated every NFL 2021 Week 16 game to determine where the value lies for football bettors across the United States.
With NFL betting picks, probabilities, odds and predicted scores featured each and every week at Dimers, check out our top plays for Sunday's NFL games.
MORE: NFL 2021 Week 16 most likely TD scorers
Sunday's NFL best bets and odds are proudly brought to you by Caesars Sportsbook who will give you $100 if the team you place a $10 Moneyline bet on scores a single point.
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Free NFL Picks for Sunday December 26, 2021
Bills vs. Patriots, 1:00pm (EST)
BET: Bills +2 (-110)
In a game that will effectively decide who reigns supreme in the AFC East, the Pats will need to get back on track after their dismal Week 15 loss to the Colts - and they'll be feeling good after a Bill Belichick masterclass in the wind against this Buffalo team only a couple of weeks ago, but the Bills are hungry.
Although it'll be icy in Foxborough, we should see a vastly different game to the one where the Pats did nothing but run the ball at Highmark Stadium. Unfortunately for New England, they'll be missing some key personnel like RB Rhamondre Stevenson who is on the Covid reserve list. With revenge on their minds, we've got the Bills being too strong.
🏈Simulator: Bills vs. Patriots
✍️Full betting preview: Bills vs. Patriots
Rams vs. Vikings, 1:00pm (EST)
BET: Rams -3 (-110)
The Rams are on a roll having won 3 in a row and aren't facing any significant injury or illness concerns for their trip to Minnesota to take on the Vikings, so it's understandable that the public money so far has been all for Los Angeles at the spread - and we can't complain.
The Vikings like close games, with all but 2 being decided by 1 score or less this season, and they've experienced some bad losses which should give any bettor some hesitation in backing them. The key for LA will be their QB in Matt Stafford and the game in the air - where the Rams rank 4th in the league for pass yards per game. The Vikings can't seem to stop the ball when it takes flight, with their defense ranking 29th in the same category. A few Stafford bombs should see this bet home comfortably.
🏈Simulator: Rams vs. Vikings
✍️Full betting preview: Rams vs. Vikings
Washington vs. Cowboys, 8:20pm (EST)
BET: Washington Team Total UNDER 17.5 Points (-120)
WFT has not met this line in 3 of the last 4 games and could be without Antonio Gibson which would be crushing to this offense that already averages only 1.86 yards per drive. The Cowboys defensively have been carrying the load for this team and really found their groove as of late, holding opponents to under 17.5 points in 2 of their last 3. The Cowboys should look to get the run game going with Zeke/Pollard to control the clock. Given the 10+ point spread, the books are predicting a Cowboys win by a wide margin and if that is the case, FG’s will no longer be needed for this WFT.
🏈Simulator: Washington vs. Cowboys
✍️Full betting preview: Washington vs. Cowboys
Free NFL Parlay For Saturday, December 25, 2021
1️⃣ Bills +2
2️⃣ Rams -3
3️⃣ Washington TT u17.5 points
🔥 Parlay these picks (+569)
NFL WEEK 16 BETTING HUB:
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MORE: FanDuel Sportsbook Bet $5, wIn $150 Christmas Offer
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MORE: BetMGM Bet $10, Win $200 if there's a TD
Full NFL Schedule Week 16 2021
Thursday December 23, 2021
Saturday December 25 (Christmas), 2021
- Cleveland Browns at Green Bay Packers, 4:30PM ET
- Indianapolis Colts vs. Arizona Cardinals, 8:15PM ET
Sunday December 26, 2021
- Detroit Lions at Atlanta Falcons, 1PM ET
- New York Giants at Philadelphia Eagles, 1PM ET
- Jacksonville Jaguars at New York Jets, 1PM ET
- Tampa Bay Buccaneers at Carolina Panthers, 1PM ET
- Los Angeles Chargers at Houston Texans, 1PM ET
- Buffalo Bills at New England Patriots, 1PM ET
- Los Angeles Rams at Minnesota Vikings, 1PM ET
- Baltimore Ravens at Cincinnati Bengals, 1PM ET
- Chicago Bears at Seattle Seahawks, 4:05PM ET
- Denver Broncos at Las Vegas Raiders, 4:25PM ET
- Pittsburgh Steelers at Kansas City Chiefs, 4:25PM ET
- Washington Football Team at Dallas Cowboys, 8:20PM ET
Monday December 27, 2021
All 2021 NFL Week 16 times are subject to change.
Flex scheduling rules apply and will be in effect through to Week 17.