NFL Week 4 straight up picks: Expert predictions for every game [2025]

At Dimers.com, we offer NFL picks straight up for Week 4 and every week, as part of our detailed NFL picks and NFL predictions coverage.

With Week 4 of the NFL season here, we've used our cutting-edge predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Gain the edge in your NFL pick 'em competitions by following our data-driven NFL Week 4 picks straight up, powered by thousands of game simulations.

Week 4 of the NFL season features 16 games, starting with the Seattle Seahawks facing the Arizona Cardinals on Thursday night and ending with the Cincinnati Bengals taking on the Denver Broncos on Monday night.

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NFL picks this week straight up: Week 4, 2025

Here are our Week 4 NFL picks, highlighting each team's chances of winning their game this week.

Seattle Seahawks vs. Arizona Cardinals

The Seahawks kick off Week 4 against the Cardinals at State Farm Stadium on Thursday night. According to our model, the Cardinals have a 58% chance of winning, while the Seahawks have a 42% chance.

For Week 4's opening game, our model highlights NFL player props with Kenneth Walker (RB) as the most likely player from the Seahawks to score the first TD at 10.6%, while Marvin Harrison (WR) is the top candidate from the Cardinals at 9.6%.

The Seattle Seahawks vs. Arizona Cardinals game at State Farm Stadium is scheduled for Thursday, September 25 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Minnesota Vikings vs. Pittsburgh Steelers

For this week's game between the Vikings and the Steelers, Minnesota is more likely to win. Our prediction model gives the Vikings a 57% chance of winning. On the other hand, there is a 43% chance that the Steelers will win.

The Minnesota Vikings vs. Pittsburgh Steelers matchup at Croke Park will take place on Sunday, September 28 at 9:30am.

As the season heats up, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

New Orleans Saints vs. Buffalo Bills

We are picking the Bills to win their game against the Saints this week, with our powerful NFL model projecting a 91% win probability for the home team. The Saints have a 9% chance of winning.

For betting purposes, the Bills are listed as -16.5 favorites, with the Saints' moneyline at +1000.

The New Orleans Saints vs. Buffalo Bills game at Highmark Stadium is slated for Sunday, September 28 at 1:00pm.

Tennessee Titans vs. Houston Texans

According to our predictive analytics model, the Texans are the team to beat in this game, with their win probability at 77%. The Titans, on the other hand, have a 23% chance of winning.

The Tennessee Titans vs. Houston Texans game at NRG Stadium is set for Sunday, September 28 at 1:00pm.

Cleveland Browns vs. Detroit Lions

The Lions have a 79% chance of winning on Sunday afternoon, compared to the Browns' 21% chance of victory. This makes the Detroit Lions our pick to win at Ford Field.

The Cleveland Browns vs. Detroit Lions matchup at Ford Field is scheduled for Sunday, September 28 at 1:00pm.

Washington Commanders vs. Atlanta Falcons

The Commanders are favored to win their Week 4 game, with our predictive analytics model giving them a 57% chance, while the Falcons enter the weekend with a 43% chance of winning at Mercedes-Benz Stadium.

When it comes to betting on this game, the Commanders' moneyline odds are set at -125, with the home team Falcons listed as +1.5 underdogs.

The Washington Commanders vs. Atlanta Falcons game at Mercedes-Benz Stadium will take place on Sunday, September 28 at 1:00pm.

Philadelphia Eagles vs. Tampa Bay Buccaneers

After 10,000 simulations of Eagles vs. Buccaneers this Sunday, our model projects the Eagles as the more likely winners with a probability of 60%. Their opponents, the Buccaneers, have a 40% chance of getting the win at home.

The Philadelphia Eagles vs. Tampa Bay Buccaneers matchup at Raymond James Stadium is slated for Sunday, September 28 at 1:00pm.

Carolina Panthers vs. New England Patriots

Our model is picking the Patriots, who have a 69% chance of winning the matchup, while the Panthers have a 31% win probability.

The Carolina Panthers vs. New England Patriots game at Gillette Stadium will take place on Sunday, September 28 at 1:00pm.

Los Angeles Chargers vs. New York Giants

The next game of Week 4 sees the Chargers take on the Giants at MetLife Stadium.

We predict the Chargers to win with a probability of 71%, while the Giants are projected to have a win chance of 29%.

As for the Vegas betting odds here, the Giants are listed as +6.5 underdogs, with the Chargers' moneyline odds posted at -280.

The Los Angeles Chargers vs. New York Giants game at MetLife Stadium is scheduled for Sunday, September 28 at 1:00pm.

Jacksonville Jaguars vs. San Francisco 49ers

The likely winner of this matchup is the 49ers, who have a projected win chance of 61%, according to DimersBOT. On the other side of this matchup, the Jaguars have a projected win probability of 39%.

The Jacksonville Jaguars vs. San Francisco 49ers matchup at Levi's Stadium is set for Sunday, September 28 at 4:05pm.

Indianapolis Colts vs. Los Angeles Rams

We have run our powerful NFL model over this week’s Colts-Rams clash 10,000 times, with the Rams coming out as the team to pick. Of those 10,000 simulations, the Rams won 6,016 times, with the Colts winning on 3,984 occasions.

The Indianapolis Colts vs. Los Angeles Rams game at SoFi Stadium is scheduled for Sunday, September 28 at 4:05pm.

Chicago Bears vs. Las Vegas Raiders

Next up is the game between the Bears and Raiders, with our model projecting the home team as the more likely victor, with the Raiders rated as having a 55% chance of getting the W. The Bears, on the other hand, are projected to have a 45% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Bears' moneyline odds set at -102 for this road game, while the hosting Raiders are listed as +1.5 underdogs.

The Chicago Bears vs. Las Vegas Raiders game at Allegiant Stadium will take place on Sunday, September 28 at 4:25pm.

Baltimore Ravens vs. Kansas City Chiefs

Our next straight up pick this week is for the Ravens to get the win against the Chiefs. After running 10,000 simulations of this matchup, the Baltimore have a win probability of 58%, with the Chiefs at 42%.

The Baltimore Ravens vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium is slated for Sunday, September 28 at 4:25pm.

Green Bay Packers vs. Dallas Cowboys

With a win probability of 69% on Sunday night, our straight up pick for this matchup is the Packers, while their opponent, the Cowboys, have a projected win chance of 31%.

The Green Bay Packers vs. Dallas Cowboys game at AT&T Stadium will take place on Sunday, September 28 at 8:20pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to find the latest player prop trends.

New York Jets vs. Miami Dolphins

The team to pick here is the Dolphins, who have a 60% chance of winning their matchup against the Jets this Sunday night.

Looking at the betting odds for this Monday Night Football clash, the Dolphins are listed as -2.5 favorites at home, with the Jets' moneyline odds available at +130.

The New York Jets vs. Miami Dolphins game at Hard Rock Stadium is scheduled for Monday, September 29 at 7:15pm.

Cincinnati Bengals vs. Denver Broncos

Our pick to win the final game of Week 4 is the Broncos, who have a win probability of 73%. Their opponents are projected to have a 27% chance of getting the W.

The Cincinnati Bengals vs. Denver Broncos game at Empower Field at Mile High is set for Monday, September 29 at 8:15pm.

Full list of NFL Week 4 picks straight up

• Cardinals (58% win probability)
• Vikings (57%)
• Bills (91%)
• Texans (77%)
• Lions (79%)
• Commanders (57%)
• Eagles (60%)
• Patriots (69%)
• Chargers (71%)
• 49ers (61%)
• Rams (60%)
• Raiders (55%)
• Ravens (58%)
• Packers (69%)
• Dolphins (60%)
• Broncos (73%)

NFL straight up picks and predictions for Week 4

The NFL Week 4 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.