NFL Week 3 straight up picks: Expert predictions for every game [2025]

At Dimers.com, we provide NFL picks straight up for Week 3 and beyond, as part of our extensive NFL picks and NFL predictions coverage.

With Week 3 of the NFL season here, we've harnessed our cutting-edge predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Gain the edge in your NFL pick 'em competitions via our data-driven NFL Week 3 picks straight up, powered by thousands of game simulations.

Week 3 of the NFL season features 16 games, starting with the Miami Dolphins facing the Buffalo Bills on Thursday night and concluding with the Detroit Lions taking on the Baltimore Ravens on Monday night.

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NFL picks this week straight up: Week 3, 2025

Here are our Week 3 NFL picks, highlighting each team's chances of winning their game this week.

Miami Dolphins vs. Buffalo Bills

The Dolphins kick off Week 3 against the Bills at Highmark Stadium on Thursday. According to our NFL model, the Bills have an 82% chance of winning, while the Dolphins have an 18% chance.

The Miami Dolphins vs. Buffalo Bills game at Highmark Stadium is scheduled for Thursday, September 18 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Indianapolis Colts vs. Tennessee Titans

For this week's game between the Colts and the Titans, Indianapolis is more likely to win. Our prediction model gives the Colts a 63% chance of winning. On the other hand, there is a 37% chance that the Titans will pull off an upset win.

The Indianapolis Colts vs. Tennessee Titans matchup at Nissan Stadium will take place on Sunday, September 21 at 1:00pm.

As the season heats up, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

Pittsburgh Steelers vs. New England Patriots

We are picking the Steelers to win their game against the Patriots this week, with our famous NFL model projecting a 59% win probability for the road team. The Patriots have a 41% chance of winning at Gillette Stadium.

For betting purposes, the Patriots are listed as +1.5 underdogs, with the Steelers' moneyline at -120.

The Pittsburgh Steelers vs. New England Patriots game at Gillette Stadium is slated for Sunday, September 21 at 1:00pm.

New York Jets vs. Tampa Bay Buccaneers

According to our predictive analytics model, the Buccaneers are the team to beat in this game, with their win probability at 74%. The Jets, on the other hand, have a 26% chance of winning.

The New York Jets vs. Tampa Bay Buccaneers game at Raymond James Stadium is set for Sunday, September 21 at 1:00pm.

Las Vegas Raiders vs. Washington Commanders

The Commanders have a 64% chance of winning on Sunday afternoon, compared to the Raiders' 36% chance of victory. This makes the Washington Commanders our pick to win at Northwest Stadium.

The Las Vegas Raiders vs. Washington Commanders matchup at Northwest Stadium is scheduled for Sunday, September 21 at 1:00pm.

Los Angeles Rams vs. Philadelphia Eagles

The Eagles are favorites to win this game, with our predictive analytics model giving them a 61% chance, while the Rams enter the weekend with a 39% chance of causing an upset at Lincoln Financial Field.

When it comes to betting on this game, the Rams' moneyline odds are set at +155, with the home team Eagles listed as -3.5 favorites.

The Los Angeles Rams vs. Philadelphia Eagles game at Lincoln Financial Field will take place on Sunday, September 21 at 1:00pm.

Atlanta Falcons vs. Carolina Panthers

After 10,000 simulations of Falcons vs. Panthers this Sunday, our model projects the Falcons as the more likely winners with a probability of 65%. Their opponents, the Panthers, have a 35% chance of getting the win at home.

The Atlanta Falcons vs. Carolina Panthers matchup at Bank of America Stadium is slated for Sunday, September 21 at 1:00pm.

Cincinnati Bengals vs. Minnesota Vikings

Our model is picking the Vikings, who have a 61% chance of winning the matchup, while the Bengals have a 39% chance of an upset win.

The Cincinnati Bengals vs. Minnesota Vikings game at U.S. Bank Stadium will take place on Sunday, September 21 at 1:00pm.

Houston Texans vs. Jacksonville Jaguars

The next game of Week 3 sees the Texans take on the Jaguars at EverBank Stadium.

We predict the Jaguars to win with a probability of 55%, while the Texans are projected to have a win chance of 45%.

As for the Vegas betting odds here, the Jaguars are listed as -0.5 favorites, with the Texans' moneyline odds posted at +102.

The Houston Texans vs. Jacksonville Jaguars game at EverBank Stadium is scheduled for Sunday, September 21 at 1:00pm.

Green Bay Packers vs. Cleveland Browns

The likely winner of this matchup is the Packers, who have a projected win chance of 80%, according to DimersBOT. On the other side of this matchup, the Browns have a projected win probability of 20%.

The Green Bay Packers vs. Cleveland Browns matchup at Huntington Bank Field is set for Sunday, September 21 at 1:00pm.

Denver Broncos vs. Los Angeles Chargers

We have run our powerful NFL model over this week’s Broncos-Chargers clash 10,000 times, with the Chargers coming out as the team to pick. Of those 10,000 simulations, the Chargers won 5,832 times, with the Broncos winning on 4,168 occasions.

The Denver Broncos vs. Los Angeles Chargers game at SoFi Stadium is scheduled for Sunday, September 21 at 4:05pm.

New Orleans Saints vs. Seattle Seahawks

Next up is the game between the Saints and Seahawks, with our model projecting the home team as the more likely victor, with the Seahawks rated as having a 76% chance of getting the W. The Saints, on the other hand, are projected to have a 24% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Saints' moneyline odds set at +310 for this road game, while the hosting Seahawks are listed as -7.5 favorites.

The New Orleans Saints vs. Seattle Seahawks game at Lumen Field will take place on Sunday, September 21 at 4:05pm.

Arizona Cardinals vs. San Francisco 49ers

Our next straight up pick this week is for the 49ers to get the win against the Cardinals. After running 10,000 simulations of this matchup, the San Francisco have a win probability of 56%, with the Cardinals at 44%.

The Arizona Cardinals vs. San Francisco 49ers game at Levi's Stadium is slated for Sunday, September 21 at 4:25pm.

Dallas Cowboys vs. Chicago Bears

With a win probability of 54% on Sunday afternoon, our straight up pick for this game is the Bears, while their opponent, the Cowboys, have a projected win chance of 46%.

The Dallas Cowboys vs. Chicago Bears game at Soldier Field will take place on Sunday, September 21 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to find the latest player prop trends.

Kansas City Chiefs vs. New York Giants

The team to pick here is the Chiefs, who have a 68% chance of winning their matchup against the Giants this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Giants are listed as +6.5 underdogs at home, with the Chiefs' moneyline odds available at -255.

The Kansas City Chiefs vs. New York Giants game at MetLife Stadium is scheduled for Sunday, September 21 at 8:20pm.

Detroit Lions vs. Baltimore Ravens

Our pick to win the final game of Week 3 is the Ravens, who have a win probability of 67%. Their opponents are projected to have a 33% chance of getting the W.

The Detroit Lions vs. Baltimore Ravens game at M&T Bank Stadium is set for Monday, September 22 at 8:15pm.

Full list of NFL Week 3 picks straight up

• Bills (82% win probability)
• Colts (63%)
• Steelers (59%)
• Buccaneers (74%)
• Commanders (64%)
• Eagles (61%)
• Falcons (65%)
• Vikings (61%)
• Jaguars (55%)
• Packers (80%)
• Chargers (58%)
• Seahawks (76%)
• 49ers (56%)
• Bears (54%)
• Chiefs (68%)
• Ravens (67%)

NFL straight up picks and predictions for Week 3

The NFL Week 3 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.