NFL Week 1 straight up picks: Expert predictions for every game [2025]

At Dimers.com, we offer NFL picks straight up for Week 1 and every week, as part of our in-depth NFL picks and NFL predictions coverage.

With Week 1 of the NFL season here, we've harnessed our state-of-the-art predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Get an advantage in your NFL pick 'em competitions with our data-driven NFL Week 1 picks straight up, powered by thousands of game simulations.

Week 1 of the NFL season features 16 games, beginning with the Dallas Cowboys facing the Philadelphia Eagles on Thursday night and ending with the Minnesota Vikings taking on the Chicago Bears on Monday night.

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NFL picks this week straight up: Week 1, 2025

Here are our Week 1 NFL picks, highlighting how likely each team is to win their game this week.

Dallas Cowboys vs. Philadelphia Eagles

The Cowboys kick off Week 1 against the Eagles at Lincoln Financial Field on Thursday night. According to our predictive analytics model, the Eagles have a 76% chance of winning, while the Cowboys have a 24% chance.

For Week 1's opening game, our model highlights NFL player props with CeeDee Lamb (WR) as the most likely player from the Cowboys to score the first TD at 7.2%, while Saquon Barkley (RB) is the top candidate from the Eagles at 15.6%.

The Dallas Cowboys vs. Philadelphia Eagles game at Lincoln Financial Field is scheduled for Thursday, September 4 at 8:20pm. All times mentioned in this article are in Eastern Standard Time (EST).

Kansas City Chiefs vs. Los Angeles Chargers

For this year's NFL Brazil game between the Chiefs and the Chargers, Kansas City is more likely to win. Our prediction model gives the Chiefs a 60% chance of winning in Sao Paulo. On the other hand, there is a 40% chance that the Chargers will win.

The Kansas City Chiefs vs. Los Angeles Chargers matchup at Corinthians Arena in Brazil will take place on Friday, September 5 at 8:00pm.

As the season begins, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Tampa Bay Buccaneers vs. Atlanta Falcons

We are picking the Buccaneers to win their game against the Falcons this week, with our trusted NFL model projecting a 58% win probability for the road team. The Falcons have a 42% chance of winning at Mercedes-Benz Stadium.

For betting purposes, the Falcons are listed as +2.5 underdogs, with the Buccaneers' moneyline at -132.

The Tampa Bay Buccaneers vs. Atlanta Falcons game at Mercedes-Benz Stadium is slated for Sunday, September 7 at 1:00pm.

Pittsburgh Steelers vs. New York Jets

According to our predictive analytics model, the Steelers are the team to beat in this game, with their win probability at 57%. The Jets, on the other hand, have a 43% chance of winning.

The Pittsburgh Steelers vs. New York Jets game at MetLife Stadium is set for Sunday, September 7 at 1:00pm.

Miami Dolphins vs. Indianapolis Colts

The Colts have a 55% chance of winning on Sunday afternoon, compared to the Dolphins' 45% chance of victory. This makes the Indianapolis Colts our pick to win at Lucas Oil Stadium.

The Miami Dolphins vs. Indianapolis Colts matchup at Lucas Oil Stadium is scheduled for Sunday, September 7 at 1:00pm.

Carolina Panthers vs. Jacksonville Jaguars

The Jaguars are favored to win their game this week, with our model giving them a 60% chance, while the Panthers enter the weekend with a 40% chance of securing a win at EverBank Stadium.

When it comes to betting on this game, the Panthers' moneyline odds are set at +155, with the home team Jaguars listed as -3.5 favorites.

The Carolina Panthers vs. Jacksonville Jaguars game at EverBank Stadium will take place on Sunday, September 7 at 1:00pm.

New York Giants vs. Washington Commanders

After 10,000 simulations of Giants vs. Commanders this Sunday, our model projects the Commanders as the more likely winners with a probability of 74%. Their opponents, the Giants, have a 26% chance of getting the win on the road.

The New York Giants vs. Washington Commanders matchup at Northwest Stadium is slated for Sunday, September 7 at 1:00pm.

Arizona Cardinals vs. New Orleans Saints

Our model is picking the Cardinals, who have a 73% chance of winning the matchup, while the Saints have a 27% win probability.

The Arizona Cardinals vs. New Orleans Saints game at Caesars Superdome will take place on Sunday, September 7 at 1:00pm.

Cincinnati Bengals vs. Cleveland Browns

The next game of Week 1 sees the Bengals take on the Browns at Huntington Bank Field.

We predict the Bengals to win with a probability of 69%, while the Browns are projected to have a win chance of 31%.

As for the Vegas betting odds here, the Browns are listed as +5.5 underdogs, with the Bengals' moneyline odds posted at -225.

The Cincinnati Bengals vs. Cleveland Browns game at Huntington Bank Field is scheduled for Sunday, September 7 at 1:00pm.

Las Vegas Raiders vs. New England Patriots

The likely winner of this matchup is the Patriots, who have a projected win chance of 59%, according to DimersBOT. On the other side of this matchup, the Raiders have a projected win probability of 41%.

The Las Vegas Raiders vs. New England Patriots matchup at Gillette Stadium is set for Sunday, September 7 at 1:00pm.

San Francisco 49ers vs. Seattle Seahawks

We have run our powerful NFL model over this week’s 49ers-Seahawks clash 10,000 times, with the 49ers coming out as the team to pick. Of those 10,000 simulations, the 49ers won 5,810 times, with the Seahawks winning on 4,190 occasions.

The San Francisco 49ers vs. Seattle Seahawks game at Lumen Field is scheduled for Sunday, September 7 at 4:05pm.

Tennessee Titans vs. Denver Broncos

Next up is the game between the Titans and Broncos, with our model projecting the home team as the more likely victor, with the Broncos rated as having a 77% chance of getting the W. The Titans, on the other hand, are projected to have a 23% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Titans' moneyline odds set at +330 for this road game, while the hosting Broncos are listed as -7.5 favorites.

The Tennessee Titans vs. Denver Broncos game at Empower Field at Mile High will take place on Sunday, September 7 at 4:05pm.

Detroit Lions vs. Green Bay Packers

Our next straight up pick this week is for the Packers to get the win against the Lions. After running 10,000 simulations of this matchup, the Green Bay have a win probability of 58%, with the Lions at 42%.

The Detroit Lions vs. Green Bay Packers game at Lambeau Field is slated for Sunday, September 7 at 4:25pm.

Houston Texans vs. Los Angeles Rams

With a win probability of 59% on Sunday afternoon, our straight up pick for this matchup is the Rams, while their opponent, the Texans, have a projected win chance of 41%.

The Houston Texans vs. Los Angeles Rams game at SoFi Stadium will take place on Sunday, September 7 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to spot the latest player prop trends.With a win probability of 59% on Sunday afternoon, our straight up pick for this game is the Rams, while their opponent, the Texans, have a projected win chance of 41%.

The Houston Texans vs. Los Angeles Rams game at SoFi Stadium will take place on Sunday, September 7 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to find the latest player prop trends.

Baltimore Ravens vs. Buffalo Bills

The team to pick here is the Bills, who have a 54% chance of winning their matchup against the Ravens this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Bills are listed as -1.5 favorites at home, with the Ravens' moneyline odds available at -108.

The Baltimore Ravens vs. Buffalo Bills game at Highmark Stadium is scheduled for Sunday, September 7 at 8:20pm.

Minnesota Vikings vs. Chicago Bears

Our pick to win the final game of Week 1 is the Vikings, who have a win probability of 61%. Their opponents are projected to have a 39% chance of getting the W.

The Minnesota Vikings vs. Chicago Bears game at Soldier Field is set for Monday, September 8 at 8:15pm.

Full list of NFL Week 1 picks straight up

• Eagles (76% win probability)
• Chiefs (60%)
• Buccaneers (58%)
• Steelers (57%)
• Colts (55%)
• Jaguars (60%)
• Commanders (74%)
• Cardinals (73%)
• Bengals (69%)
• Patriots (59%)
• 49ers (58%)
• Broncos (77%)
• Packers (58%)
• Rams (59%)
• Bills (54%)
• Vikings (61%)

NFL straight up picks and predictions for Week 1

The NFL Week 1 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.