Bills vs. Lions NFL Week 12 Betting Preview, Picks and Odds - November 24, 2022

The Buffalo Bills haven't quite been themselves lately, but they'll feel good about their chances of picking up a Thanksgiving Day win over the Detroit Lions at 12:30PM ET on Thursday, November 24.  

Here is Dimers' free betting preview of Bills vs. Lions, plus our picks, score prediction, best odds and player props are featured in this article.

If you haven't already, you should consider signing up for DraftKings ➡️ here ⬅️ as you can turn a $5 pre-game moneyline bet on any game into a free $150 if your team wins. 

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Bills vs. Lions Betting Preview 

The Bills earned a 31-23 win over the Cleveland Browns last week and they avoided a three-game losing streak in doing so. Buffalo is currently in a serious battle for the top spot in the AFC East, as all the other teams in the division look somewhat dangerous. With that said, the Bills will be heading into Thanksgiving Day hoping to beat a Lions team that has now won and covered in three games in a row. 

Detroit suddenly looks a lot better on the defensive side of the ball. That's huge for the Lions, who were already very explosive offensively. But this Detroit team is still just 3-6 on the season and Buffalo is a ridiculous 8-0 against the spread when facing teams with losing records in the second half of the year since the start of the 2020-21 season. The Bills just don't let games get away when they're expected to win, and they have actually won those games by an average of 18.0 points per game. 

Will Detroit find a way to keep Buffalo's passing game in check? If the Lions can avoid giving up big plays, they just might find a way to stay in this one until late in the fourth quarter. 

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Who will win Bills vs. Lions?

Using cutting-edge machine learning and data, Dimers.com has simulated Thursday's Bills-Lions NFL game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Bills a 77% chance of beating the Lions in Week 12 of the NFL season.

More: Full Betting Analysis for Bills vs. Lions

Bills vs. Lions Current Odds

• Spread: Lions +9.5 (-104), Bills -9.5 (-110)
• Moneyline: Lions +380, Bills -425
• Total: Over/Under 54.5 (-108/-110)

Point Spread, Moneyline and Over/Under

The Lions are listed as +9.5 underdogs against the Bills, with -104 at FanDuel Sportsbook the best odds currently available.

For the favored Bills (-9.5) to cover the spread, Caesars Sportsbook has the best odds currently on offer at -110.

FanDuel Sportsbook currently has the best moneyline odds for the Lions at +380, which means you can bet $100 to profit $380, earning a total payout of $480, if they win.

Elsewhere, PointsBet currently has the best moneyline odds for the Bills at -425, where you can risk $425 to win $100, for a total payout of $525, if they come out on top.

The Over/Under for total points scored is set at 54.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -108, while BetMGM currently has the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the Lions (+9.5) are a 53% chance of covering the spread, while the 54.5-point Over/Under is a 53% chance of going Under.

More: Predictions for Every NFL Week 12 Matchup

Best Bets for Bills vs. Lions

• Spread: Lions +9.5 @ -104 via FanDuel Sportsbook (53% probability)
• Moneyline: Lions @ +380 via FanDuel Sportsbook (2.3% edge)
• Total: Under 54.5 @ -110 via BetMGM (53% probability)

Dimers' best bets are based on complex modeling and betting expertise to help you make smarter investments with your state's legal sportsbooks.

While the Bills are more likely to win the game, according to DimersBOT, taking the Lions moneyline is the best option because of the 2.3% edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen here at Dimers.com is one of the keys to achieving long-term profitability as a sports bettor.

Bills vs. Lions Prediction

Dimers.com's predicted final score for Buffalo vs. Detroit at Ford Field in Week 12 has the Bills winning 31-22.

Click or tap on See Matchup for more.

Dimers has full coverage of this week's Bills-Lions matchup in Week 12, including pregame predictions, free picks, and live win probabilities.

Bills vs. Lions Player Props

Who will score an anytime touchdown in Bills vs. Lions? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Bills and Lions, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you select the best prop picks for Thursday's game.

According to DimersBOT, Buffalo's Stefon Diggs is most likely to score the first touchdown in Bills vs. Lions.

DimersBOT gives Diggs a 13.2% chance of scoring the first TD at Ford Field, while the Bills WR is a 59.1% chance of scoring an anytime touchdown.

Scroll down for the complete list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Buffalo Bills

• Stefon Diggs: 13.2% probability
• Gabe Davis: 8.4% probability
• Josh Allen: 8.2% probability
• Devin Singletary: 7.1% probability
• Dawson Knox: 6.7% probability

Detroit Lions

• Jamaal Williams: 11.2% probability
• Amon-Ra St. Brown: 5.5% probability
• D'Andre Swift: 4.4% probability
• Justin Jackson: 3.6% probability
• Josh Reynolds: 3.5% probability

Anytime Touchdown Scorer Probabilities

Buffalo Bills

• Stefon Diggs: 59.1% probability
• Gabe Davis: 42.5% probability
• Josh Allen: 40.4% probability
• Devin Singletary: 38.0% probability
• Dawson Knox: 35.2% probability

Detroit Lions

• Jamaal Williams: 52.3% probability
• Amon-Ra St. Brown: 30.2% probability
• D'Andre Swift: 24.5% probability
• Josh Reynolds: 21.0% probability
• Justin Jackson: 19.7% probability

Bills-Lions Projected Player Stats

Of the starting quarterbacks, the Bills' Josh Allen is projected to have a big game with 286 passing yards, while the Lions' Jared Goff is expected to throw for 253 yards.

Bills Starting QB

• Josh Allen: 286 projected yards

Lions Starting QB

• Jared Goff: 253 projected yards

Bills Rushing

• Devin Singletary: 54 projected yards
• Josh Allen: 50 projected yards
• James Cook: 13 projected yards

Lions Rushing

• Jamaal Williams: 63 projected yards
• D'Andre Swift: 31 projected yards
• Justin Jackson: 21 projected yards

Bills Receiving

• Stefon Diggs: 100 projected yards
• Gabe Davis: 80 projected yards
• Dawson Knox: 39 projected yards
• Isaiah McKenzie: 26 projected yards
• Devin Singletary: 22 projected yards

Lions Receiving

• Amon-Ra St. Brown: 81 projected yards
• DJ Chark: 34 projected yards
• Jameson Williams: 31 projected yards
• Kalif Raymond: 31 projected yards
• Josh Reynolds: 28 projected yards

Don't forget, DimersBOT updates regularly, so refresh this page for the latest betting insights before Bills vs. Lions on Thursday November 24, 2022.

Bills vs. Lions 2022

The NFL Week 12 action between the Lions and Bills at Ford Field is scheduled to commence at 12:30PM ET.

• Who: Buffalo Bills vs. Detroit Lions
• Date: Thursday November 24, 2022
• Time: 12:30PM ET / 9:30AM PT
• Venue: Ford Field

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