NFL best bets today: Week 4 picks include two spread plays [9/28/2025]

Today’s NFL picks for September 28, 2025 are here, with Sunday’s NFL best bets built on tens of thousands of predictive simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Packers vs. Cowboys and Colts vs. Rams, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Sunday, September 28, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of NFL best bets today [9/28, updated 4:02PM ET]

After crunching the numbers and conducting thousands of simulations, our leading predictive analytics model has figured out the best football bets for Sunday, September 28, 2025.

Cowboys +7 (-115)

• Probability: 59.7%
• Edge: 6.2%
• Matchup: Packers vs. Cowboys (8:20PM ET, Sunday)

Our model has pinpointed a high-probability NFL betting opportunity today, which comes in the Packers vs. Cowboys game. We recommend a spread bet on Cowboys +7 at -115 odds, with our analysis showing a 59.7% chance of hitting and a compelling edge of 6.2%.

Colts +3.5 (-105)

• Probability: 58.9%
• Edge: 7.7%
• Matchup: Colts vs. Rams (4:05PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's sports action, this time in the matchup between the Colts and Rams. We suggest placing a spread wager on Colts +3.5 at -105 odds, with a 58.9% probability delivering a 7.7% edge.

Bears vs. Raiders over 48 points (-110)

• Probability: 55.3%
• Edge: 3.0%
• Matchup: Bears vs. Raiders (4:25PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's football action, this time in the Bears vs. Raiders matchup. We recommend an over/under bet on over 48 points at -110 odds. Our projections shows a 55.3% probability and 3.0% edge for this wager.

NFL best bets: Sunday, 9/28/2025

As of 4:02PM ET, here are our top three NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Packers vs. Cowboys	Cowboys +7	-115 @ DraftKings	59.7%	6.2%
Colts vs. Rams	Colts +3.5	-105 @ DraftKings	58.9%	7.7%
Bears vs. Raiders	Over 48 Points	-110 @ BetMGM	55.3%	3.0%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to four NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 28, 2025.

List of upcoming NFL games to bet on [9/28/2025]

• Jaguars vs. 49ers (4:05PM ET, Sunday)
• Colts vs. Rams (4:05PM ET, Sunday)
• Bears vs. Raiders (4:25PM ET, Sunday)
• Ravens vs. Chiefs (4:25PM ET, Sunday)
• Packers vs. Cowboys (8:20PM ET, Sunday)

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More on NFL

The bets on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for September 28, 2025, featuring plays such as Cowboys +7 and Colts +3.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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