NFL best bets today: Week 2 picks include two moneyline plays [9/14/2025]

Today’s NFL picks for September 14, 2025 are here, with Sunday’s NFL best bets driven by tens of thousands of data simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Eagles vs. Chiefs and Broncos vs. Colts, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Sunday, September 14, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of NFL best bets today [9/14, updated 4:01PM ET]

After crunching the numbers and conducting thousands of simulations, our famous predictive analytics model has figured out the best football bets for Sunday, September 14, 2025.

Eagles ML (-122)

• Probability: 59.7%
• Edge: 4.7%
• Matchup: Eagles vs. Chiefs (4:25PM ET, Sunday)

Our model has pinpointed a high-probability NFL betting opportunity today, which comes in the Eagles vs. Chiefs matchup. We recommend a bet on the Eagles ML at -122 odds, with our analysis showing a 59.7% chance of hitting and a compelling edge of 4.7%.

Broncos ML (-122)

• Probability: 59.3%
• Edge: 4.3%
• Matchup: Broncos vs. Colts (4:05PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's sports action, this time in the matchup between the Broncos and Colts. We suggest placing a wager on Broncos ML at -122 odds, with a 59.3% probability delivering a 4.3% edge.

Eagles vs. Chiefs over 46.5 points (-102)

• Probability: 56%
• Edge: 5.5%
• Matchup: Eagles vs. Chiefs (4:25PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's football action, this time in the Eagles vs. Chiefs game. We recommend an over/under bet on over 46.5 points at -102 odds. Our projections shows a 56% probability and 5.5% edge for this wager.

NFL best bets: Sunday, 9/14/2025

As of 4:01PM ET, here are our top three NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Eagles vs. Chiefs	Eagles ML	-122 @ DraftKings	59.7%	4.7%
Broncos vs. Colts	Broncos ML	-122 @ FanDuel	59.3%	4.3%
Eagles vs. Chiefs	Over 46.5 Points	-102 @ DraftKings	56%	5.5%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to three NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 14, 2025.

List of upcoming NFL games to bet on [9/14/2025]

• Panthers vs. Cardinals (4:05PM ET, Sunday)
• Broncos vs. Colts (4:05PM ET, Sunday)
• Eagles vs. Chiefs (4:25PM ET, Sunday)
• Falcons vs. Vikings (8:20PM ET, Sunday)

See How Dimers Pro Enhances Your Best Bets

Ready to take your betting to the next level? See how Dimers Pro boosts our best bets by watching this explainer video.

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More on NFL

The bets on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for September 14, 2025, featuring plays such as Eagles ML and Broncos ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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