NFL best bets today: Week 1 picks include two moneyline plays [9/7/2025]

Today’s NFL picks for September 7, 2025 are here, with Sunday’s NFL best bets backed by tens of thousands of data simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Texans vs. Rams and 49ers vs. Seahawks, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Sunday, September 7, 2025, including our full suite of picks and best bets for today and the week ahead.

List of NFL best bets today [9/7, updated 4:02PM ET]

After digging deep into the numbers and running thousands of simulations, our leading predictive analytics model has figured out the best football bets for Sunday, September 7, 2025.

Texans +3.5 (-118)

• Probability: 64.7%
• Edge: 10.6%
• Matchup: Texans vs. Rams (4:25PM ET, Sunday)

Our model has pinpointed a high-probability NFL betting opportunity today, which comes in the Texans vs. Rams game. We recommend a spread bet on Texans +3.5 at -118 odds, with our analysis showing a 64.7% chance of hitting and a compelling edge of 10.6%.

49ers ML (-125)

• Probability: 58.7%
• Edge: 3.2%
• Matchup: 49ers vs. Seahawks (4:05PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's sports action, this time in the game between the 49ers and Seahawks. We suggest placing a wager on 49ers ML at -125 odds, with a 58.7% probability delivering a 3.2% edge.

Ravens ML (-118)

• Probability: 58.4%
• Edge: 4.3%
• Matchup: Ravens vs. Bills (8:20PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's football action,this time in the Ravens vs. Bills game. We recommend a bet on Ravens ML at -118 odds. Our model shows a 58.4% probability and 4.3% edge for this wager.

NFL best bets: Sunday, 9/7/2025

As of 4:02PM ET, here are our top three NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Texans vs. Rams	Texans +3.5	-118 @ DraftKings	64.7%	10.6%
49ers vs. Seahawks	49ers ML	-125 @ BetMGM	58.7%	3.2%
Ravens vs. Bills	Ravens ML	-118 @ FanDuel	58.4%	4.3%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to five NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 7, 2025.

List of upcoming NFL games to bet on [9/7/2025]

• 49ers vs. Seahawks (4:05PM ET, Sunday)
• Titans vs. Broncos (4:05PM ET, Sunday)
• Lions vs. Packers (4:25PM ET, Sunday)
• Texans vs. Rams (4:25PM ET, Sunday)
• Ravens vs. Bills (8:20PM ET, Sunday)

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More about NFL

The best on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for September 7, 2025, featuring plays such as Texans +3.5 and 49ers ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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