NFL best bets today: Week 2 MNF picks include Buccaneers vs. Texans play [9/15/2025]

Today’s NFL picks for September 15, 2025 are here, with Monday’s NFL best bets fueled by tens of thousands of data simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Buccaneers vs. Texans and Chargers vs. Raiders, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Monday, September 15, 2025, including our full set of picks and best bets for today and the week ahead.

List of NFL best bets tonight [9/15, updated 6:31PM ET]

After crunching the numbers and conducting thousands of simulations, our independent predictive analytics model has figured out the best football bets for Monday, September 15, 2025.

Buccaneers +2.5 (-105)

• Probability: 58.2%
• Edge: 7.0%
• Matchup: Buccaneers vs. Texans (7:00PM ET, Monday)

Our model has pinpointed a high-probability NFL betting opportunity tonight, which comes in the Buccaneers vs. Texans game. We recommend a spread bet on Buccaneers +2.5 at -105 odds, with our analysis showing a 58.2% chance of hitting and a compelling edge of 7.0%.

Chargers vs. Raiders under 46.5 points (-102)

• Probability: 53.2%
• Edge: 2.7%
• Matchup: Chargers vs. Raiders (10:00PM ET, Monday)

Our model has found another strong NFL bet for Monday's sports action, this time in the matchup between the Chargers and Raiders. We suggest placing an over/under wager on under 46.5 points at -102 odds, with a 53.2% probability delivering a 2.7% edge.

NFL best bets: Monday, 9/15/2025

As of 6:31PM ET, here are our top two NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Buccaneers vs. Texans	Buccaneers +2.5	-105 @ BetMGM	58.2%	7.0%
Chargers vs. Raiders	Under 46.5 Points	-102 @ DraftKings	53.2%	2.7%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to two NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 15, 2025.

List of upcoming NFL games to bet on [9/15/2025]

• Buccaneers vs. Texans (7:00PM ET, Monday)
• Chargers vs. Raiders (10:00PM ET, Monday)

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More about NFL

The bets on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for September 15, 2025, featuring plays such as Buccaneers +2.5 and under 46.5 points in the Chargers vs. Raiders matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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