Yankees vs. Cardinals prediction: Yankees predicted to win Saturday's MLB matchup [8/16/2025]

The St. Louis Cardinals and New York Yankees will lock horns in MLB action at Busch Stadium on Saturday, starting at 7:15PM ET.

The Cardinals will have Sonny Gray (11-5, 4.06 ERA) as their starting pitcher, pitting him against Max Fried (12-5, 2.94 ERA) for the Yankees.

Based on the latest simulation results, Dimers' proven MLB model predicts the Yankees as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Yankees vs. Cardinals predictions page.

Cardinals vs. Yankees prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Yankees and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Yankees a 55% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 58% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Yankees vs. Cardinals odds [8/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Cardinals
Run Line	-1.5 (+125)	+1.5 (-142)
Moneyline	-140	+124
Total	o7.5 (-102)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Yankees vs. Cardinals picks and best bets

Our model's biggest edge in today's Yankees vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Yankees vs. Cardinals game-day updates and essential details

Saturday's MLB action between the Cardinals and Yankees at Busch Stadium is scheduled to commence at 7:15PM ET.

• Who: New York Yankees vs. St. Louis Cardinals
• Date: Saturday, August 16, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Saturday's Yankees vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting launching on December 1, 2025, Dimers has you covered with the latest news and the best pre-registration offers in MO.

Sports betting deal available for Kansas and Illinois

To make the most of Saturday's massive day of sports, headlined by a huge day of MLB, check out details on the latest Bet365 bonus available in the states of Kansas and Illinois that secures $150 in bonus bets from a $5 bet. Don't miss out!

Conclusion

We predict the Yankees, with a 55% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date predictions for the World Series, American League, National League and each division.