Yankees vs. Cardinals prediction: Yankees predicted to win Friday's MLB matchup [8/15/2025]

The St. Louis Cardinals and New York Yankees are scheduled to meet in MLB action at Busch Stadium on Friday, starting at 8:15PM ET.

The Cardinals will send Andre Pallante (6-9, 4.95 ERA) to the mound, pitting him against Luis Gil (0-1, 7.27 ERA) for the Yankees.

Based on updated simulation results, Dimers' advanced MLB model predicts the Yankees as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Yankees vs. Cardinals predictions page.

Cardinals vs. Yankees prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Yankees and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Yankees a 56% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 57% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Yankees vs. Cardinals odds [8/15/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Cardinals
Run Line	-1.5 (+119)	+1.5 (-134)
Moneyline	-143	+124
Total	o8.5 (-121)	u8.5 (+105)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Cardinals picks and best bets

Our model's strongest edge in today's Yankees vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Yankees vs. Cardinals game-day updates and essential details

Friday's MLB matchup between the Cardinals and Yankees at Busch Stadium is scheduled to start at 8:15PM ET.

• Who: New York Yankees vs. St. Louis Cardinals
• Date: Friday, August 15, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Friday's Yankees vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 56% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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