Yankees vs. Twins prediction: Why Yankees are favored to win Wednesday's MLB matchup [9/17/2025]

The Minnesota Twins will face the New York Yankees in MLB action at Target Field on Wednesday, commencing at 7:40PM ET.

The Twins will have Taj Bradley (6-7, 4.88 ERA) as their starting pitcher, while the Yankees have opted for Luis Gil (4-1, 2.83 ERA).

Based on the latest simulations, Dimers' proven MLB model predicts the Yankees as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Yankees-Twins game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 58%, with the Twins at 42%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Yankees vs. Twins predictions page.

Twins vs. Yankees prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Yankees and Twins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Yankees a 58% chance of defeating the Twins.

According to our model, the Twins (+1.5) have a 54% chance of covering the run line, while the 9-run over/under has a 54% chance of going over.

Yankees vs. Twins odds [9/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Twins
Run Line	-1.5 (+104)	+1.5 (-121)
Moneyline	-156	+135
Total	o9 (-120)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Yankees vs. Twins picks and best bets

Our model's strongest edge in today's Yankees vs. Twins matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Yankees vs. Twins game-day updates and essential details

Wednesday's MLB action between the Twins and Yankees at Target Field is scheduled to start at 7:40PM ET.

• Who: New York Yankees vs. Minnesota Twins
• Date: Wednesday, September 17, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Target Field

Dimers' in-depth preview of Wednesday's Yankees vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 58% win probability, will likely beat the Twins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.