Yankees vs. Twins prediction: Why Yankees are favored to win Tuesday's MLB matchup [9/16/2025]

MLB action continues on Tuesday at 7:40PM ET as the New York Yankees lock horns with the Minnesota Twins at Target Field.

Zebby Matthews (4-5, 5.06 ERA) will be on the bump for the Twins, while the Yankees will counter with Cam Schlittler (3-3, 3.05 ERA).

Based on updated simulations, Dimers' advanced MLB model projects the Yankees as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Yankees vs. Twins predictions page.

Twins vs. Yankees prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the Yankees and Twins 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 59% chance of beating the Twins.

According to our model, the Twins (+1.5) have a 53% chance of covering the run line, while the 9-run over/under has a 53% chance of going over.

Yankees vs. Twins odds [9/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Twins
Run Line	-1.5 (+100)	+1.5 (-118)
Moneyline	-165	+142
Total	o9 (-109)	u9 (-108)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Twins picks and best bets

Our model's strongest edge in today's Yankees vs. Twins matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Yankees vs. Twins game-day updates and essential details

Tuesday's MLB matchup between the Twins and Yankees at Target Field is scheduled to commence at 7:40PM ET.

• Who: New York Yankees vs. Minnesota Twins
• Date: Tuesday, September 16, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Target Field

Dimers' comprehensive preview of Tuesday's Yankees vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 59% win probability, will likely beat the Twins on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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