Yankees vs. Astros prediction: Yankees favored to win Wednesday's MLB matchup [9/3/2025]

The Houston Astros will face the New York Yankees in MLB action at Daikin Park on Wednesday, starting at 8:10PM ET.

The Astros will send Jason Alexander (4-1, 4.61 ERA) to the mound, pitting him against Will Warren (8-6, 4.30 ERA) for the Yankees.

Based on updated simulations, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Yankees-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 55%, with the Astros at 45%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Yankees vs. Astros predictions page.

Astros vs. Yankees prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Yankees and Astros 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 55% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 58% chance of covering the run line, while the 9-run over/under has a 53% chance of going over.

Yankees vs. Astros odds [9/3/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Astros
Run Line	-1.5 (+115)	+1.5 (-134)
Moneyline	-142	+125
Total	o9 (-115)	u9 (+101)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Astros picks and best bets

Our model's biggest edge in today's Yankees vs. Astros matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Yankees vs. Astros game-day updates and essential details

Wednesday's MLB matchup between the Astros and Yankees at Daikin Park is scheduled to begin at 8:10PM ET.

• Who: New York Yankees vs. Houston Astros
• Date: Wednesday, September 3, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's full preview of Wednesday's Yankees vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 55% win probability, will likely beat the Astros on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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