Yankees vs. Astros prediction: Yankees favored to win Thursday's MLB matchup [9/4/2025]

The Houston Astros will square off with the New York Yankees in MLB action at Daikin Park on Thursday, starting at 7:40PM ET.

Cristian Javier (1-1, 3.38 ERA) will start on the mound for the Astros, while the Yankees are going with Carlos Rodón (15-7, 3.18 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Yankees as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Yankees vs. Astros predictions page.

Astros vs. Yankees prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Thursday's MLB matchup between the Yankees and Astros 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 56% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 57% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of going over.

Yankees vs. Astros odds [9/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Astros
Run Line	-1.5 (+116)	+1.5 (-135)
Moneyline	-142	+120
Total	o9 (-102)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Astros picks and best bets

Our model's strongest edge in today's Yankees vs. Astros matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Yankees vs. Astros game-day updates and essential details

Thursday's MLB game between the Astros and Yankees at Daikin Park is scheduled to commence at 7:40PM ET.

• Who: New York Yankees vs. Houston Astros
• Date: Thursday, September 4, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Thursday's Yankees vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 56% win probability, will likely beat the Astros on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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