Yankees vs. Red Sox prediction: Yankees favored to win Friday's MLB matchup [9/12/2025]

The Boston Red Sox and New York Yankees will meet in MLB action at Fenway Park on Friday, starting at 7:10PM ET.

Lucas Giolito (10-3, 3.38 ERA) will start on the mound for the Red Sox, while the Yankees have opted for Luis Gil (3-1, 3.31 ERA).

Based on the latest simulation results, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Yankees vs. Red Sox predictions page.

Red Sox vs. Yankees prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Yankees and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 53% chance of defeating the Red Sox.

According to our model, the Red Sox (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 56% chance of going over.

Yankees vs. Red Sox odds [9/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Red Sox
Run Line	-1.5 (+138)	+1.5 (-160)
Moneyline	-118	+102
Total	o8.5 (-110)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Yankees vs. Red Sox picks and best bets

Our model's biggest edge in today's Yankees vs. Red Sox matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Yankees vs. Red Sox game-day updates and essential details

Friday's MLB action between the Red Sox and Yankees at Fenway Park is scheduled to begin at 7:10PM ET.

• Who: New York Yankees vs. Boston Red Sox
• Date: Friday, September 12, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Fenway Park

Dimers' in-depth preview of Friday's Yankees vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Red Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Maryland sports fans

To make the most of Friday's mammoth day of sports, headlined by a huge day and night of MLB and college football!

Conclusion

We predict the Yankees, with a 53% win probability, will likely beat the Red Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date predictions for the World Series, American League, National League and each division.