Yankees vs. Orioles prediction: Yankees favored to win Sunday's MLB matchup [9/21/2025]

The Baltimore Orioles and New York Yankees will lock horns in MLB action at Oriole Park at Camden Yards on Sunday, starting at 1:35PM ET.

The Orioles will start Kyle Bradish (1-1, 2.46 ERA), pitting him against Cam Schlittler (3-3, 3.41 ERA) for the Yankees.

Based on updated simulation results, Dimers' advanced MLB model predicts the Yankees as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Yankees-Orioles game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Yankees with a win probability of 53%, while the Orioles have 47%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Yankees vs. Orioles predictions page.

Orioles vs. Yankees prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Sunday's MLB game between the Yankees and Orioles 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 53% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 58% chance of covering the run line, while the over/under total of 8.5 runs has a 55% chance of going over.

Yankees vs. Orioles odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Orioles
Run Line	-1.5 (+123)	+1.5 (-145)
Moneyline	-132	+115
Total	o8.5 (-104)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Orioles picks and best bets

Our model's biggest edge in today's Yankees vs. Orioles matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Yankees vs. Orioles game-day updates and essential details

Sunday's MLB matchup between the Orioles and Yankees at Oriole Park at Camden Yards is scheduled to start at 1:35PM ET.

• Who: New York Yankees vs. Baltimore Orioles
• Date: Sunday, September 21, 2025
• Time: 1:35PM ET/10:35AM PT
• Venue: Oriole Park at Camden Yards

Dimers' full preview of Sunday's Yankees vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 53% win probability, will likely beat the Orioles on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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