Yankees vs. Orioles prediction: Yankees favored to win Saturday's MLB matchup [9/20/2025]

The Baltimore Orioles will take on the New York Yankees in MLB action at Oriole Park at Camden Yards on Saturday, beginning at 7:05PM ET.

The Orioles will start Tomoyuki Sugano (10-8, 4.39 ERA), while the Yankees have opted for Carlos Rodón (16-9, 3.11 ERA).

Based on updated simulation results, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Yankees vs. Orioles predictions page.

Orioles vs. Yankees prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Yankees and Orioles 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 63% chance of beating the Orioles.

According to our model, the Yankees (-1.5) have a 51% chance of covering the run line, while the 9-run over/under has a 54% chance of going over.

Yankees vs. Orioles odds [9/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Yankees	Orioles
Run Line	-1.5 (-120)	+1.5 (+105)
Moneyline	-196	+165
Total	o9 (-105)	u9 (-114)

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Orioles picks and best bets

Our model's strongest edge in today's Yankees vs. Orioles matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Yankees vs. Orioles game-day updates and essential details

Saturday's MLB action between the Orioles and Yankees at Oriole Park at Camden Yards is scheduled to commence at 7:05PM ET.

• Who: New York Yankees vs. Baltimore Orioles
• Date: Saturday, September 20, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Oriole Park at Camden Yards

Dimers' in-depth preview of Saturday's Yankees vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Yankees vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 63% win probability, will likely beat the Orioles on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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