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Yankees vs. Orioles prediction: Yankees favored to win Friday's MLB matchup [9/19/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get New York Yankees vs Baltimore Orioles predictions for MLB Friday.
The Baltimore Orioles and New York Yankees will lock horns in MLB action at Oriole Park at Camden Yards on Friday, starting at 7:05PM ET.
Trevor Rogers (8-2, 1.43 ERA) will get the ball for the Orioles, while the Yankees will counter with Will Warren (8-7, 4.44 ERA).
Based on the latest simulation results, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.
For a closer look at Friday's matchup, including best bets and picks, visit our interactive Yankees vs. Orioles predictions page.
Orioles vs. Yankees prediction: Who will win, cover the run line?
Using powerful machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Yankees and Orioles 10,000 times as part of our MLB predictions coverage.
Our leading predictive model currently gives the Yankees a 51% chance of defeating the Orioles.
According to our model, the Orioles (+1.5) have a 61% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of going over.
Yankees vs. Orioles odds [9/19/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Yankees | Orioles |
|---|---|---|
| Run Line | -1.5 (+146) | +1.5 (-165) |
| Moneyline | -113 | -102 |
| Total | o9 (+100) | u9 (-110) |
All odds are correct at the time of publication and are subject to change.
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Yankees vs. Orioles picks and best bets
Our model's biggest edge in today's Yankees vs. Orioles matchup is on the run line.
Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's best bets today
Calling Our Shot produces daily MLB betting content, including the predictions featured below.
Yankees vs. Orioles game-day updates and essential details
Friday's MLB matchup between the Orioles and Yankees at Oriole Park at Camden Yards is scheduled to begin at 7:05PM ET.
- Who: New York Yankees vs. Baltimore Orioles
- Date: Friday, September 19, 2025
- Time: 7:05PM ET/4:05PM PT
- Venue: Oriole Park at Camden Yards
Dimers' in-depth preview of Friday's Yankees vs. Orioles matchup includes our prediction, picks and the latest betting odds.
Before making any Yankees vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Yankees, with a 51% win probability, will likely beat the Orioles on Friday.
AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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