Mets vs. Nationals prediction: Mets favored to win Thursday's MLB matchup [8/21/2025]

The Washington Nationals will take on the New York Mets in MLB action at Nationals Park on Thursday, starting at 4:05PM ET.

The Nationals will send MacKenzie Gore (5-12, 4.04 ERA) to the mound, while the Mets are going with Sean Manaea (1-1, 4.78 ERA).

Based on the latest simulation results, Dimers' advanced MLB model projects the Mets as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Mets vs. Nationals predictions page.

Nationals vs. Mets prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Thursday's MLB matchup between the Mets and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Mets a 53% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of going over.

Mets vs. Nationals odds [8/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mets	Nationals
Run Line	-1.5 (+130)	+1.5 (-149)
Moneyline	-130	+114
Total	o8 (-110)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Mets vs. Nationals picks and best bets

Our model's strongest edge in today's Mets vs. Nationals matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Mets vs. Nationals game-day updates and essential details

Thursday's MLB action between the Nationals and Mets at Nationals Park is scheduled to start at 4:05PM ET.

• Who: New York Mets vs. Washington Nationals
• Date: Thursday, August 21, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Thursday's Mets vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Mets vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mets, with a 53% win probability, will likely beat the Nationals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Mets vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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