Mets vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [7/30/2025]

The San Diego Padres will square off with the New York Mets in MLB action at PETCO Park on Wednesday, beginning at 4:10PM ET.

Yu Darvish (0-3, 9.18 ERA) will get the ball for the Padres, while the Mets will counter with Clay Holmes (9-5, 3.40 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game. "Our team has simulated the outcome of Wednesday's Mets-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 51%, with the Mets at 49%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Mets vs. Padres predictions page.

Padres vs. Mets Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Mets and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 51% chance of defeating the Mets.

According to our model, the Mets (+1.5) have a 66% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Mets vs. Padres Odds [7/30/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mets	Padres
Run Line	+1.5 (-220)	-1.5 (+165)
Moneyline	+103	-118
Total	o8.5 (-105)	u8.5 (-113)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Mets vs. Padres Picks and Best Bets

Our model's strongest edge in today's Mets vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Mets vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB action between the Padres and Mets at PETCO Park is scheduled to commence at 4:10PM ET.

• Who: New York Mets vs. San Diego Padres
• Date: Wednesday, July 30, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's full preview of Wednesday's Mets vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Mets vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 51% win probability, will likely beat the Mets on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mets vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest predictions for the World Series, American League, National League and each division.