Mets vs. Phillies prediction: Why Philadelphia is favored to win Wednesday's MLB matchup [9/10/2025]

The Philadelphia Phillies will take on the New York Mets in MLB action at Citizens Bank Park on Wednesday, starting at 6:45PM ET.

Cristopher Sánchez (12-5, 2.60 ERA) will be on the bump for the Phillies, pitting him against Clay Holmes (11-7, 3.61 ERA) for the Mets.

Based on the latest simulations, Dimers' advanced MLB model predicts the Phillies as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Mets-Phillies game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Phillies' chance of winning at 57%, with the Mets at 43%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Mets vs. Phillies predictions page.

Phillies vs. Mets prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Mets and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 57% chance of beating the Mets.

According to our model, the Mets (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has a 55% chance of going over.

Mets vs. Phillies odds [9/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mets	Phillies
Run Line	+1.5 (-154)	-1.5 (+140)
Moneyline	+140	-162
Total	o7.5 (-105)	u7.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Mets vs. Phillies picks and best bets

Our model's strongest edge in today's Mets vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Mets vs. Phillies game-day updates and essential details

Wednesday's MLB action between the Phillies and Mets at Citizens Bank Park is scheduled to start at 6:45PM ET.

• Who: New York Mets vs. Philadelphia Phillies
• Date: Wednesday, September 10, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers' in-depth preview of Wednesday's Mets vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Mets vs. Phillies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Phillies, with a 57% win probability, will likely beat the Mets on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mets vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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