Mets vs. Cubs prediction: Why Mets are favored to win Tuesday's MLB matchup [9/23/2025]

The Chicago Cubs will square off with the New York Mets in MLB action at Wrigley Field on Tuesday, starting at 7:40PM ET.

The Cubs will send Cade Horton (11-4, 2.66 ERA) to the mound, while the Mets are going with David Peterson (9-6, 3.98 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Mets as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Mets vs. Cubs predictions page.

Cubs vs. Mets prediction: Who will win?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB matchup between the Mets and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mets a 51% chance of defeating the Cubs.

According to our model, the over/under total of 7.5 runs has a 58% chance of going over.

Mets vs. Cubs odds [9/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Mets	Cubs
Moneyline	-108	-108
Total	o7.5 (+102)	u7.5 (-124)

All odds are correct at the time of publication and are subject to change.

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Mets vs. Cubs picks and best bets

Our model's strongest edge in today's Mets vs. Cubs matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Mets vs. Cubs game-day updates and essential details

Tuesday's MLB matchup between the Cubs and Mets at Wrigley Field is scheduled to start at 7:40PM ET.

• Who: New York Mets vs. Chicago Cubs
• Date: Tuesday, September 23, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Wrigley Field

Dimers' full preview of Tuesday's Mets vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Mets vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mets, with a 51% win probability, will likely beat the Cubs on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Mets vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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