Mets vs. Cubs prediction: Why Mets are favored to win Thursday's MLB matchup [9/25/2025]

MLB action continues on Thursday at 7:40PM ET as the New York Mets square off with the Chicago Cubs at Wrigley Field.

The Cubs will have Shota Imanaga (9-7, 3.37 ERA) as their starting pitcher, while the Mets are going with Nolan McLean (4-1, 1.27 ERA).

Based on the latest simulations, Dimers' proven MLB model predicts the Mets as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Mets vs. Cubs predictions page.

Cubs vs. Mets prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Thursday's MLB game between the Mets and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mets a 52% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 60% chance of covering the run line, while the 7.5-run over/under has a 60% chance of going over.

Mets vs. Cubs odds [9/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mets	Cubs
Run Line	-1.5 (+154)	+1.5 (-176)
Moneyline	-115	+100
Total	o7.5 (-108)	u7.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Mets vs. Cubs picks and best bets

Our model's strongest edge in today's Mets vs. Cubs matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Mets vs. Cubs game-day updates and essential details

Thursday's MLB action between the Cubs and Mets at Wrigley Field is scheduled to begin at 7:40PM ET.

• Who: New York Mets vs. Chicago Cubs
• Date: Thursday, September 25, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Wrigley Field

Dimers' full preview of Thursday's Mets vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Mets vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mets, with a 52% win probability, will likely beat the Cubs on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Mets vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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