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Mets vs. Red Sox Prediction: Boston Predicted to Win Wednesday's MLB Matchup [5/21/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Wednesday's New York Mets vs Boston Red Sox matchup.
The Boston Red Sox and New York Mets are scheduled to meet in MLB action at Fenway Park on Wednesday, starting at 6:45PM ET.
Garrett Crochet (4-3, 2.00 ERA) will be on the bump for the Red Sox, up against Tylor Megill (3-4, 3.74 ERA) for the Mets.
Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Red Sox as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's NY Mets-Boston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"With the latest updates and numerous other variables, we estimate the Red Sox' chance of winning at 59%, with the Mets at 41%."
For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Mets vs. Red Sox predictions page.
Red Sox vs. Mets Prediction: Who Will Win, Cover the Run Line?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Mets and Red Sox 10,000 times as part of our MLB predictions coverage.
Our independent predictive model gives the Red Sox a 59% chance of beating the Mets.
According to our model, the Mets (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.
Mets vs. Red Sox Odds [5/21/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Mets | Red Sox |
|---|---|---|
| Run Line | +1.5 (-170) | -1.5 (+145) |
| Moneyline | +128 | -148 |
| Total | o7.5 (+100) | u7.5 (-122) |
All odds are correct at the time of publication and are subject to change.
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Mets vs. Red Sox Picks and Best Bets
Our model's biggest edge in today's Mets vs. Red Sox matchup is on the run line.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free ⚾️ Picks
Calling Our Shot produces daily MLB betting content, including the best bets featured below.
Mets vs. Red Sox Game-Day Updates and Essential Details
Wednesday's MLB matchup between the Red Sox and Mets at Fenway Park is scheduled to commence at 6:45PM ET.
- Who: New York Mets vs. Boston Red Sox
- Date: Wednesday, May 21, 2025
- Time: 6:45PM ET/3:45PM PT
- Venue: Fenway Park
Dimers.com's in-depth preview of Wednesday's Mets vs. Red Sox matchup includes our prediction, picks and the latest betting odds.
Before making any NY Mets vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Red Sox, with a 59% win probability, will likely beat the Mets on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Mets vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate predictions for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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